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. 2021 Apr 20;9:72. doi: 10.1186/s40478-021-01179-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig 3. — Complement C3 deposition decreases with continuous CR2Crry treatment. a Representative Imaris images of processed 40x z-stacked immunofluorescence images acquired by confocal microscopy from two regions adjacent to site of TBI impact (as shown in the atlas image represented in this figure) from vehicle treatment, 1-week CR2Crry treatment, continuous CR2Crry treatment, and naïve mice (9 months). Hoechst (blue), C3 (red), NeuN (green), and Iba-1 (aqua). b Quantification of C3 intensity. c Quantification of number of C3/NeuN interactions per frame. d Quantification of number of C3/NeuN/Iba1 interaction per frame. One-way ANOVA with Bonferroni correction for multiple comparisons. Unpaired T-test: continuous vs. vehicle. Error bars = Mean +/- SEM. *p < 0.05, **p < 0.01. n = 6–9/group. e 3D representative example of interactions (white arrows) between C3 (red)/ NeuN (green) and C3 (red)/ NeuN (green)/ Iba1 (aqua).