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. 2021 Apr 20;54:14. doi: 10.1186/s40659-021-00337-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Downregulation of circ_0008285 suppresses proliferation, migration, and invasion of HTR-8/SVneo cells under high glucose condition. a Confirmed inhibition effect of siRNAs on the circ_0008285 expression in HTR-8/SVneo cells. b Confirmation of the expression of circ_0008285 in the supernatant after HTR-8/SVneo cells transfection with siRNAs. c Silencing of circ_0008285 inhibits the proliferation of HTR-8/SVneo cells cultivated in high glucose medium. d EdU staining confirms the inhibition effects of HTR-8/SVneo cell proliferation by silencing circ_0008285 under high glucose treatment. e Silencing of circ_0008285 inhibits the migration and invasion of HTR-8/SVneo cells in high glucose. NC, siNC. Mean ± SEM (n = 3), *P < 0.05, **P < 0.01, ****P < 0.0001