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. 2021 Apr 20;21:227. doi: 10.1186/s12935-021-01909-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Restoration of miR-539 inhibited cell proliferation and promoted cell apoptosis in 143b and MG63 cells. a The data show that the expression of miR-539 was much lower in osteosarcoma cell lines (143b, MG63) than in an osteoblastic cell line. b The data show that the expression of miR-539 in the miR-539 mimics group (both 143b and MG63) was much higher than that in the miR-539 mimic-NC group and that the difference between the two groups was statistically significant (P < 0.01). c The cell proliferation of 143b osteosarcoma cells. d The cell proliferation of MG63 osteosarcoma cells. The pictures in c and d show that the cell proliferation in the miR-539 mimic groups was much lower than that in the miR-539 mimic-NC groups (P < 0.01). e–f Apoptosis of osteosarcoma 143b cells. g–h Apoptosis of osteosarcoma MG63 cells. All of the above pictures show that the miR-539 mimic groups had higher rates of apoptosis than the miR-539 mimic-NC groups in both the 143b and MG63 osteosarcoma cell lines (P < 0.01)