TABLE 1.
Eculizumab, C5 and C5‐eculizumab concentrations in serum and placental tissue
| [Eculizumab] | [C5] a | [C5‐Eculizumab] | ||
|---|---|---|---|---|
| μg/mL serum or μg/g tissue | μg/mL serum or μg/g tissue | μg/mL serum or μg/g tissue | ||
| Pregnancy 1 | Maternal | 259 | 118 | 234 |
| Cord | 3.5 | 73 | 26 | |
| Placenta (mean ± SD) b | 41 ± 3 | 20 ± 3 | 19 ± 3 | |
| Pregnancy 2 | Maternal | 232 | 152 | 252 |
| Cord | 2.7 | 78 | 22 | |
| Placenta (mean ± SD) b | 45 ± 4 | 30 ± 2 | 32 ± 2 |
a
The concentration C5 in cord blood relative to maternal blood was in agreement with a previously reported range of 54‐61%. 16 Reference values of C5 in adults are 42‐93 μg/mL. 8
b
Placental concentrations represent the mean ± SD of three samples per placenta, excised at random areas midway between the cord and distal edge of the placenta.