TABLE 2.
The association between pooled ABCB1 1199G>A and 3435C>T genotype and tacrolimus concentrations
| ABCB1 genotype | Wildtype | One variant allele | >One variant allele | P‐value |
|---|---|---|---|---|
| Month 3 | (n = 37) | (n = 79) | (n = 51) | |
| Dose (mg) | 5.0 (4.0–7.0) | 6.0 (4.0–8.0) | 6.0 (4.0–9.0) | 0.48 |
| [Tac]blood (ng/mL) | 7.8 (6.4–9.0) | 7.5 (6.0–9.6) | 7.3 (5.9–8.6) | 0.65 |
| [Tac]blood/dose | 1.7 (0.9–2.1) | 1.5 (0.8–2.1) | 1.3 (0.8–1.9) | 0.33 |
| [Tac]cells (pg/106 cells) | 24.5 (16.0–33.0) | 27.0 (19.5–40.5) | 28.5 (19.8–35.8) | 0.29 |
| [Tac] cells/dose | 5.3 (3.7–6.4) | 4.6 (3.0–8.7) | 4.5 (2.8–7.3) | 0.68 |
| [Tac]cells/[Tac]blood | 3.1 (1.8–4.0) | 3.9 (2.8–5.4) | 3.6 (2.4–5.6) | 0.12 |
| Month 6 | (n = 29) | (n = 61) | (n = 35) | |
| [Tac]cells/[Tac]blood | 3.5 (2.4–4.3) | 3.4 (2.4–5.4) | 3.7 (2.5–5.1) | 0.72 |
| Month 12 | (n = 15) | (n = 17) | (n = 20) | |
| [Tac]cells/[Tac]blood | 3.8 (2.7–4.4) | 3.6 (2.9–4.3) | 3.3 (2.4–5.6) | 0.99 |
[Tac]cells indicates the unadjusted tacrolimus pre‐dose concentration in peripheral blood mononuclear cell concentration. [Tac]blood indicates the unadjusted tacrolimus pre‐dose whole blood concentration. Data is shown as median (IQR). P denotes the comparison between groups by Kruskal‐Wallis test.