. 2020 Nov 24;87(4):1918–1929. doi: 10.1111/bcp.14585

TABLE 3.

Poor, intermediate and extensive metabolizers and the association with tacrolimus concentrations

Metabolizers	Poor	Intermediate	Extensive	P‐value
Month 3	(n = 16)	(n = 117)	(n = 33)
Dose (mg)	3.0 (2.8–5.5) ^b	5.0 (4.0–6.0) ^c	10.0 (9.0–12.0) ^b ^, ^c	<0.001
[Tac]_blood (ng/mL)	8.2 (7.0–9.8)	7.5 (6.1–9.0)	7.5 (6.1–9.2)	0.59
[Tac]_blood/dose	2.3 (1.7–3.1) ^a ^, ^b	1.6 (1.1–2.1) ^a ^, ^c	0.7 (0.5–0.9) ^b ^, ^c	<0.001
[Tac]_cells (pg/10⁶ cells)	25.3 (18.8–29.6)	27.5 (19.0–37.0)	24.0 (17.5–34.5)	0.47
[Tac]_cells/dose	7.3 (4.9–8.3) ^b	5.3 (3.6–8.8) ^c	2.4 (1.3–3.6) ^b ^, ^c	<0.001
[Tac]_cells/[Tac]_blood	3.0 (2.5–4.3)	3.8 (2.6–5.6)	3.5 (2.1–4.2)	0.25
Month 6	(n = 14)	(n = 83)	(n = 25)
[Tac]_cells/[Tac]_blood	2.3 (1.9–2.9) ^a	3.6 (2.5–5.1) ^a	3.9 (2.6–5.8)	0.02
Month 12	(n = 6)	(n = 36)	(n = 9)
[Tac]_cells/[Tac]_blood	3.6 (2.9–4.3)	3.6 (2.4–4.6)	3.6 (2.9–5.8)	0.91

[Tac]_cells indicates the unadjusted tacrolimus pre‐dose concentration in peripheral blood mononuclear cell concentration. [Tac]_blood indicates the unadjusted tacrolimus pre‐dose whole blood concentration. Data is shown as median (IQR). P denotes the comparison between groups by Kruskal‐Wallis test.

^{^a}

P < 0.05 comparing poor metabolizers to intermediate metabolizers with Bonferroni correction.

^{^b}

P < 0.05 comparing poor metabolizers to extensive metabolizers with Bonferroni correction.

^{^c}

P < 0.05 comparing intermediate metabolizers to extensive metabolizers with Bonferroni correction.