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. 2021 Apr 16;218(6):e20201776. doi: 10.1084/jem.20201776

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© 2021 Harlé et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 5. — Abolition of MHCII in LECs exacerbates CIA. (A–C) CIA was induced in Tx-treated MHCII^WT and MHCII^ΔProx1 mice. (A) Clinical scores (paw thickness) were assessed at indicated time points. Data are representative of two independent experiments with six to eight mice/group. (B) Inflammatory scores were assessed by histological analysis on knee sections at day 41 (seven or eight mice/group). Representative images are provided, and arrowheads indicate areas of inflammation. Histograms represent global inflammation scores (sum of two knees per mouse). (C) Flow cytometry analysis of indicated T cell subsets infiltrating hind-joint legs at day 31, five or six mice/group. Representative dot plots are provided. Histograms represent the frequencies or the numbers of indicated cells in joints. Two-way ANOVA (A) and unpaired t test (B and C); * P < 0.05 and ** P < 0.01. Error bars correspond to SEM (A) and to lower and higher values for each group (B and C).