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Recombinant C5a causes destruction of highly differentiated HAE. Addition of C5a (1 μg/mL) to highly differentiated HAE resulted in massive destruction of the tissue model in absence of SARS-CoV-2 infection. On the left, BF, Hoechst, and WGA and on the right, Hoechst and WGA are depicted. Multiple fields were analyzed, verifying the damage caused by addition of recombinant C5a. BF, Brightfield; WGA, wheat germ agglutinin.
