Table 2.
Multivariate Risk Factors Associated With Infection
| Variable | Total (N = 774) | Infected (n = 359 [46%]) | Not Infected (n = 415 [54%]) | P Value | HR (95% CI) |
|---|---|---|---|---|---|
| Sex, female | 177 (23) | 74 (21) | 103 (25) | .668 | 1.06 (0.80-1.41) |
| Age, y | 62 (54-68) | 62 (54-68) | 62 (54-69) | .004 | 0.98 (0.97-0.99) |
| Nonrespiratory SOFA score | 1 (1-2) | 1 (1-2) | 1 (1-2) | .108 | 0.91 (0.81-1.02) |
| Pao2 to Fio2 ratio | |||||
| > 200 | 118 (15) | 46 (13) | 72 (17) | … | … |
| ≥ 200 and < 100a | 382 (49) | 180 (50) | 202 (49) | .762 | 1.06 (0.74-1.50) |
| ≤ 100a | 250 (32) | 122 (34) | 128 (31) | .196 | 1.28 (0.88-1.87) |
| PEEP, cm H2O | 12 (10 -14) | 12 (10 -14) | 10 (10 -14) | .021 | 1.05 (1.01-1.10) |
| pH | |||||
| ≥ 7.35 and < 7.45 | 301 (39) | 137 (38) | 164 (40) | … | … |
| < 7.25b | 41 (5) | 25 (7) | 16 (4) | .716 | 1.07 (0.73-1.58) |
| ≥ 7.25 and < 7.35b | 188 (24) | 102 (28) | 86 (21) | .519 | 0.92 (0.70-1.19) |
| ≥ 7.45b | 225 (29) | 89 (25) | 136 (33) | .309 | 0.85 (0.62-1.16) |
| Antibiotic therapyc | |||||
| No antibiotic | 240 (31) | 130 (36) | 110 (27) | … | … |
| Narrow spectrumd | 294 (38) | 130 (36) | 164 (40) | .121 | 0.78 (0.56-1.07) |
| Broad spectrumd | 240 (31) | 99 (28) | 141 (34) | .002 | 0.61 (0.44-0.84) |
| Anakinrae | 89 (12) | 52 (14) | 37 (9) | .799 | 0.93 (0.53-1.62) |
| Tocilizumabe | 187 (24) | 85 (24) | 102 (25) | .425 | 1.60 (0.50-5.12) |
| Corticosteroidse | |||||
| High dose | 36 (5) | 17 (5) | 19 (5) | .822 | 1.07 (0.58-1.97) |
| Low dose | 171 (22) | 80 (22) | 91 (22) | .178 | 0.80 (0.57-1.11) |
Data are presented as No. (%) of the included patients or median (interquartile range), unless otherwise indicated. HR = hazard ratio; PEEP = positive end expiratory pressure; SOFA = Sequential Organ Failure Assessment.
a
vs Pao2 to Fio2 ratio of > 200.
b
vs pH of ≥ and < 7.45.
c
At ICU admission.
d
vs no antibiotic.
e
At least 24 h before infection.