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. 2021 Feb 2;8(2):e953. doi: 10.1212/NXI.0000000000000953

Figure 3. Accumulation of Neutrophils in the CNS During ALS.

Figure 3

(A) Spinal cord tissue from control and ALS participants (cervical sections, collected postmortem) was analyzed for neutrophils using flow cytometry. (B) Total neutrophils were quantified in postmortem tissue of the cervical, thoracic, and lumbar spinal cord sections from control and ALS participants. Mean neutrophil counts were: cervical cord, ALS = 10.9 × 103/g, control = 1.6 × 103/g, p = 0.049; thoracic cord, ALS = 3.8 × 103/g, control = 0.7 × 103/g, p = 0.002; and lumbar cord, ALS = 8.4 × 103/g, control = 1.5 × 103/g, p = 0.194. (C) Neutrophil accumulation in the CNS of male and female ALS study participants is compared in the cervical, thoracic, and lumbar sections of the spinal cord. Mean neutrophil counts were: cervical cord, males 12.2 × 103/g, females 9.7 × 103/g, p = 0.686; thoracic cord, males 4.9 × 103/g, females 2.6 × 103/g, p = 0.343; lumbar cord, males 10.6 × 103/g, females 6.2 × 103/g, p = 0.314. *p < 0.05. ALS = amyotrophic lateral sclerosis; FSC = forward scatter.