Table 3.
Immunohistochemistry for Different Histologic Components in Combined SCLC (n = 10)
| Case | Component | CD56 | ChrA | Syn | TTF-1 | CK7 | Ki67 | p63 | Napsin A |
|---|---|---|---|---|---|---|---|---|---|
| 1 | SCLC | + | focal/weak+ | strong+ | + | + | ~100 | − | np |
| GUH54 | Squamous | − | − | − | − | − | 80 | + | np |
| 2 | SCLC | + | Patchy+ | + | − | − | ~100 | − | np |
| GUH81 | Squamous | − | − | − | − | − | 80 | + | np |
| 3 | SCLC | + | Focal+ | + | + | Patchy+ | np | n/a | − |
| GUH95 | Poorly differentiated adenocarcinoma | − | − | − | − | + | np | n/a | Focal+ |
| 4 | SCLC | + | np | Patchy+ | − | − | 80 | − | np |
| GUH98 | Squamous | − | np | − | − | + | 50-60 | + | np |
| 5 | SCLC | Patchy+ | − | − | − | + | np | np | np |
| GUH90 | Squamous | − | − | − | − | − | np | np | np |
| 6 | SCLC | + | − | − | − | + | 70-80 | − | np |
| GUH93 | Squamous | − | − | − | − | − | 40-50 | + | np |
| 7 | SCLC | + | + | + | + | + | n/a | ||
| GUH68 | Adenocarcinoma | − | 30 | n/a | + | ||||
| 8 | SCLC | + | + | + | + | + | 80 | n/a | np |
| GUH45 | Poorly differentiated LCNEC | + | Patchy+ | + | − | − | 20 | n/a | np |
| 9 | SCLC | + | + | + | + | − | 50 | n/a | np |
| GUH164 | LCNEC | + | + | + | + | Dot-like+ | 80 | n/a | np |
| 10 | SCLC with clear cell change | + | − | − | − | Focal+ | 80 | n/a | np |
| GUH167 | LCNEC | + | − | − | − | Focal+ | 100 | n/a | np |
ChrA, chromogranin A; Syn, synaptophysin; TTF-1, thyroid transcription factor 1; CK7, cytokeratin 7; GUH, Georgetown University Hospital; n/a, not applicable; np, not present; LCNEC, large cell neuroendocrine carcinoma.