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[Preprint]. 2021 Apr 12:2021.04.11.439398. [Version 1] doi: 10.1101/2021.04.11.439398

Fig. 4.

Fig. 4.

Peripheral projections of nervus terminalis (NT) neurons and their presumptive relationship with ACE2-expressing neurons in the olfactory epithelium and known SARS-CoV-2 infection. NT neurons innervate blood vessels (BV), Bowman gland (BG) cells, and the olfactory epithelium (OE). Peripheral projections of NT neurons according to Larsell (1950). Cells expressing ACE2 are indicated in green, including sustentacular cells (SUS) and BG cells. Both of these cell types have been shown to express ACE2 (Bilinska et al., 2020; Brann et al., 2020; Chen et al., 2020; Ye et al., 2020; Zhang et al., 2020; Klingenstein et al., 2021). Cell types that have been documented to be infected by SARS-CoV-2 are indicated with pink asterisks. SARS-CoV-2 localization in SUS cells according to Bryche et al., 2020; de Melo et al., 2020; Leist et al., 2020; Ye et al., 2020; Zhang et al., 2020; Zheng et al., 2020, and in BG cells according to Bryche et al., 2020; Leist et al., 2020; Ye et al., 2020.