Table 1. Cell composition analysis of MSI-H versus MSS and MSI-L versus MSS tumors in TCGA-COAD.
| Cell-Type | MSI-H vs MSS (n = 242) | MSI-H vs MSI-L (n = 116) | MSI-L vs MSS (n = 231) | Significant in
MSI-H vs MSS/MSI-L |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| T-Statistic | P | FDR | T-Statistic | P | FDR | T-Statistic | P | FDR | ||
| B | -3.29 | 1.14E-03 | 2.16E-03 | -2.19 | 0.03 | 0.08 | -0.73 | 0.47 | 0.68 | True |
| CD4+T | -2.08 | 0.04 | 0.053 | -1.29 | 0.20 | 0.27 | 0.88 | 0.38 | 0.68 | False |
| CD8+T | 7.87 | 1.37E-13 | 1.30E-12 | 3.59 | 5.09E-04 | 2.41E-03 | 1.05 | 0.30 | 0.68 | True |
| Colonocytes | -4.26 | 3.03E-05 | 7.20E-05 | -2.68 | 8.58E-03 | 0.02 | 1.39 | 0.17 | 0.53 | True |
| CyclingTA | 6.57 | 3.26E-10 | 1.55E-09 | 4.29 | 3.94E-05 | 3.74E-04 | 0.82 | 0.41 | 0.68 | True |
| DC | 7.11 | 1.40E-11 | 8.87E-11 | 3.65 | 4.14E-04 | 2.42E-03 | 1.52 | 0.13 | 0.53 | True |
| Enteroendocrine | 4.89 | 1.92E-06 | 6.08E-06 | 2.72 | 7.63E-03 | 0.02 | -0.18 | 0.86 | 0.92 | True |
| Fibroblast | -0.19 | 0.85 | 0.90 | 0.17 | 0.91 | 0.96 | -0.89 | 0.37 | 0.68 | False |
| Glia | 3.07 | 2.34E-03 | 3.71E-03 | 1.28 | 0.20 | 0.27 | -0.50 | 0.62 | 0.84 | True |
| Goblet | 1.92 | 0.06 | 0.08 | 0.46 | 0.65 | 0.82 | 1.85 | 0.07 | 0.53 | False |
| ILC | -0.31 | 0.76 | 0.85 | 0.31 | 0.76 | 0.88 | -0.73 | 0.47 | 0.68 | False |
| Macrophage | 4.63 | 6.05E-06 | 1.64E-05 | 2.00 | 0.048 | 0.09 | -0.11 | 0.92 | 0.92 | True |
| Mast | 1.82 | 0.07 | 0.08 | 1.34 | 0.18 | 0.27 | 0.19 | 0.85 | 0.92 | False |
| Microvascular | -3.66 | 3.13E-04 | 6.60E-04 | -2.09 | 0.04 | 0.08 | 1.42 | 0.16 | 0.53 | True |
| Myofibroblast | 0.01 | 0.99 | 0.99 | 0.05 | 0.96 | 0.96 | -0.86 | 0.39 | 0.68 | False |
| NK | 2.44 | 0.02 | 0.02 | 1.30 | 0.20 | 0.27 | 0.15 | 0.88 | 0.92 | True |
| Pericyte | -3.23 | 1.42E-03 | 2.45E-03 | -0.27 | 0.79 | 0.88 | -1.72 | 0.09 | 0.53 | True |
| Postcapillary Venule | 6.21 | 2.49E-09 | 9.46E-09 | 3.07 | 2.73E-03 | 0.01 | -0.20 | 0.85 | 0.92 | True |
| Stem | -10.84 | 2.03E-22 | 3.86E-21 | -6.52 | 2.41E-09 | 4.58E-08 | -1.60 | 0.11 | 0.53 | True |
Positive test statistic indicates increased cell content in tumors with greater MSI. FDR corrections were calculated for each regression analysis individually and FDR significance was set at 5%. Bond fold indicates cell-types that pass FDR correction for that regression analysis.