Fig. 1. Treatment with a DP1 agonist increases mortality in PVM-infected mice.

a, b WT BALB/c mice were inoculated with PVM (1 pfu) at postnatal day (PND) 7 (0 dpi). Mice were treated (i.n. route) daily with DP1 agonist (BW245c; 1 mg/kg) or vehicle from 3 dpi onwards. c, d Survival and body weight were monitored daily. Survival curves are plotted using Kaplan–Meier methods and the difference between the subgroups calculated using the Log-rank (Mental–Cox) test (pooled data from two independent experiments with n = 6–17 mice/group). Weight gain data are presented as mean ± SEM and pooled from two independent experiments with n = 6–16 mice/group. Differences between the groups were analyzed using two-way ANOVA. *p < 0.05; **p < 0.01; ***p < 0.001.