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. 2021 Jan 8;64(1):e9. doi: 10.1192/j.eurpsy.2021.1

Figure 3.

Figure 3.

The DAT expression at striatum in chronic SD stress mouse model treated with VPA. (A) Representative western blot reveals the expression levels of DAT at striatum in mice. (B) Quantification of western blot data. Each group contained eight independent samples. The result indicated that the DAT level at striatum significantly increased in SD group compared to control group (indicated all of data sub-grouped by control (N = 16) or SD mice group (N = 16), p < 0.001). Considering the effect of 3-week VPA treatment, the DAT expression significantly decreased in SD + VPA group compared with the SD + saline, while there was not different between control + VPA and control + saline (p = 0.230). Moreover, although the reduced level of DAT expression in SD + VPA group was significantly higher than that in control + VPA (p < 0.05), the levels were not significantly different between the SD + VPA and control + saline groups. Data were expressed as mean ± SEM (N = 8 per group). *p < 0.05, ***p < 0.001 Abbreviations: SD, social defeat; VPA, valproate; DAT, dopamine transporter.