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Stapled peptide K peptide enhances cytotoxicity in human cells (4A-4B). Stapled peptide K has minimal effect on Rev1+/+ (Fig. 4 A) and Rev1−/− (Fig. 4B) MEF cells, but increases UV-induced cytotoxicity only in Rev1+/+ cells (Fig. 4A) in a Cell Titer Glo (CTG) assay. 4C shows relative increase in HPRT mutagenesis in HT1080 cells. n=6; error bars represent SD; statistical significance was determined by Student’s two-tailed t test: ***P<0.001.
