Table 4.
PFS and OS in solitary fibrous tumors and hemangiopericytomas: univariate analysis. Abbreviations: 95 CI = 95% confidence interval; GTR = gross total removal; PFS = progression‐free survival; OS = overall survival; Grade I = hypercellularity (−), mitosis<5, necrosis (−); Grade IIa = mitosis < 5, variable cellularity; necrosis (−); Grade IIb = mitosis ≥ 5, variable cellularity, necrosis (−); Grade III = hypercellularity (+); mitosis ≥ 5; necrosis (+).
| Variables | Number of patients (%) | PFS months | OS months | ||||
|---|---|---|---|---|---|---|---|
| Median | 95% CI | Log rank | Median | 95% CI | Log rank | ||
| Extent of surgery | 0.016 | 0.043 | |||||
| GTR (+) | 38 (52.8%) | 128.7 | 74.5–182.9 | NR | — | ||
| GTR (−) | 34 (47.2%) | 60.0 | 20.9–99.1 | 170.4 | 55.1–285.4 | ||
| Histological subtype | 0.041 | 0.045 | |||||
| Solitary fibrous tumor | 29 (40.3%) | NR | — | NR | — | ||
| Hemangiopericytoma | 43 (59.7%) | 80.9 | 45.1–116.8 | 170.4 | — | ||
| Mitoses | 0.001 | 0.003 | |||||
| <5 per 10 high‐power fields | 51 (70.8%) | 128.7 | 59.1–198.2 | NR | — | ||
| >5 per 10 high‐power fields | 21 (29.2%) | 44.8 | 24.1–65.4 | 116.4 | 62.0–170.9 | ||
| Hypercellularity | 0.00 | 0.038 | |||||
| Absent | 29 (40.3%) | 128.7 | — | NR | — | ||
| Present | 43 (59.7%) | 60.0 | 17.3–102.7 | 170.4 | 86.5–254.3 | ||
| Necrosis | 0.065 | 0.016 | |||||
| Absent | 57 (79.2%) | 95.0 | 45.7–144.3 | NR | — | ||
| Present | 15 (20.8%) | 60.0 | 28.9–91.2 | 125.0 | 104.3–145.7 | ||
| MIB1 Index (55 patients) | 0.046 | 0.161 | |||||
| <10% | 27 (49.1%) | NR | — | NR | — | ||
| ≥10% | 28 (50.9%) | 47.3 | 37.1–57.4 | 170.4 | 66.3–274.5 | ||
| Marseille grading system | 0.003 | 0.001 | |||||
| Grade I | 25 (34.7%) | 128.7 | — | NR | — | ||
| Grade IIa | 26 (36.1%) | 84.5 | 73.8–95.2 | NR | — | ||
| Grade IIb | 14 (19.4%) | 44.8 | 34.1–55.4 | 90.6 | 41.3–140.0 | ||
| Grade III | 7 (9.7%) | 32.1 | 7.5–56.6 | 88.1 | 26.2–149.9 | ||
The bold in log rank underlines the statistically significant parameters.