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. 2012 Jan 13;22(5):636–653. doi: 10.1111/j.1750-3639.2011.00560.x

Figure 1.

Figure 1

A. Memory performance in the V‐maze shows significant differences between APP/PS1 mice and corresponding WT from the age of 6 months onwards. Student's t‐test shows a reduction in the recognition index of APP/PS1 mice at 6, 9 and 12/14 months when compared with the corresponding WT littermates. B. Active avoidance test shows a decrease in the learning performance in APP/PS1 mice when compared with age‐matched WT littermates. Student's t‐test shows a reduction in the conditioned changes of APP/PS1 mice at 6, 9 and 12 months when compared with the corresponding age controls. *P < 0.05, **P < 0.01, ***P < 0.001 compared with age‐matched WT mice (Student's t‐test). #P < 0.05 compared with animals from the same genotype aged 3 months (Tukey's post hoc test).