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Double‐labeling immunofluorescence and confocal microscopy showing altered phospho‐tau deposition (red, B, E, H, K) in association with increased neuroketal immunoreactivity in plaques (green, A, D, G, J). C, F, I, L: merge. Nuclei are stained in blue (DRAQ5). APP/PS1 mice aged 6 and 9 months. A–F, bar = 25 µm; G–L, bar = 25 µm.
