Table 1.
Clinical and neuropathological characteristics of included PD patients, AD patients and controls. Abbreviations: PD = Parkinson's disease; PDD = Parkinson's disease with dementia; CTRL = control; AD = Alzheimer's disease; PMI = post‐mortem interval in hours; CSF = cerebrospinal fluid; NA = not applicable; ND = not determined.
| Subject | Diagnosis | PD Braak stage | AD Braak stage | Amyloid load* | Disease duration (years)† | Sex | Age | PMI (h) | pH CSF | Cause of death |
|---|---|---|---|---|---|---|---|---|---|---|
| NBB06‐002 | PD | 5 | 2 | B | 12 | F | 84 | 7:25 | 6.85 | Old age and shortness of breath |
| NBB94‐092 | PD | 4 | 0 | O | 4 | F | 77 | 9:40 | 6.86 | Euthanasia |
| NBB98‐043 | PD | 5 | 1 | O | 17 | F | 81 | 4:10 | 6.86 | Pneumonia |
| NBB98‐064 | PDD | 6 | 1 | B | 16 | F | 74 | 4:35 | 6.5 | Pneumonia |
| NBB99‐014 | PDD | 6 | 2 | B | 7 | F | 72 | 3:25 | 6.46 | Pneumonia and heart failure |
| NBB99‐069 | PD | 5 | 1 | O | 15 | F | 79 | 5:20 | 6.62 | Kidney failure complicated by heart failure |
| NBB96‐078 | CTRL | 0 | 2 | ND | NA | F | 87 | 8:00 | 6.91 | Heart failure |
| NBB03‐040 | CTRL | 0 | 0 | B | NA | F | 73 | 4:00 | 6.47 | Pulmonary fibrosis, rhabdomyolysis and progressive renal insufficiency |
| NBB03‐013 | CTRL | 0 | 1 | O | NA | F | 82 | 11:30 | 6.77 | Congestive heart failure |
| NBB95‐101 | CTRL | 0 | 1 | O | NA | F | 73 | 5:30 | 6.38 | Cardiac arrest |
| NBB98‐104 | CTRL | 0 | 2 | A | NA | F | 74 | 7:25 | 6.95 | Intestinal necrosis secondary to thrombosis |
| NBB00‐032 | CTRL | 0 | 1 | A | NA | F | 78 | 6:30 | 7.02 | Heart failure |
| Additional subjects included for immunohistochemistry | ||||||||||
| NBB07‐090 | PD | 6 | 2 | B | 22 | F | 70 | 7:05 | 6.64 | Pneumonia |
| NBB07‐008 | PD | 6 | 1 | B | 6 | M | 80 | 7:05 | 6.34 | Pneumonia |
| NBB97‐043 | CTRL | 0 | ND | ND | NA | M | 68 | 10:10 | 7.08 | Cardiac arrest |
| NBB02‐050 | AD | 0 | 4 | B | 7 | F | 95 | 4:10 | 6.45 | Myocardial infarction |
| NBB02‐021 | AD | 0 | 6 | C | 6 | F | 64 | 3:40 | 6.65 | Pneumonia |
| NBB07‐027 | AD | 0 | 6 | C | 2 | M | 60 | 6:15 | 6.58 | Dehydration |
| NBB07‐080 | AD | 0 | 5 | C | 3 | F | 90 | 5:00 | 6.36 | Unknown |
*
The load of amyloid was scored according to the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) criteria (41).
†
Disease duration in years, starting from timepoint of clinical diagnosis.