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. 2021 Apr 16;478(7):1377–1397. doi: 10.1042/BCJ20200502

Figure 3. Chemical structures of compounds inhibiting SIKs.

Figure 3.

Chemical structures of compounds inhibiting SIKs at low nM concentrations that have been used to study the functions of SIKs in cells and in vivo. KIN-112, HG-9-91-01, YKL-05-099, YKL-06-061, YKL-06-062, Dasatinib and Bosutinib target the gatekeeper site on SIKs (Figure 1C) whereas MRT67307 and MRT199665 do not. *Pterosin B treatment mimics several effects of SIK3 KO in hepatocytes and chondrocytes but is not thought to be a direct inhibitor of SIK3.