Table 2. .
Studies included in the systematic review and meta-analysis
| Author(s) | Year | Title | Journal | DOI |
|---|---|---|---|---|
| Weiller et al. | 1995 | Recovery from Wernicke’s aphasia: A positron emission tomographic study | Annals of Neurology | 10.1002/ana.410370605 |
| Belin et al. | 1996 | Recovery from nonfluent aphasia after melodic intonation therapy: A PET study | Neurology | 10.1212/wnl.47.6.1504 |
| Ohyama et al. | 1996 | Role of the nondominant hemisphere and undamaged area during word repetition in poststroke aphasics: A PET activation study | Stroke | 10.1161/01.str.27.5.897 |
| Heiss et al. | 1997 | Speech-induced cerebral metabolic activation reflects recovery from aphasia | Journal of the Neurological Sciences | 10.1016/s0022-510x(96)00252-3 |
| Karbe et al. | 1998 | Brain plasticity in poststroke aphasia: What is the contribution of the right hemisphere? | Brain and Language | 10.1006/brln.1998.1961 |
| Cao, Vikingstad, George, Johnson, & Welch | 1999 | Cortical language activation in stroke patients recovering from aphasia with functional MRI | Stroke | 10.1161/01.str.30.11.2331 |
| Heiss et al. | 1999 | Differential capacity of left and right hemispheric areas for compensation of poststroke aphasia | Annals of Neurology | 10.1002/1531-8249(199904)45:4<430::aid-ana3>3.0.co;2-p |
| Kessler, Thiel, Karbe, & Heiss | 2000 | Piracetam improves activated blood flow and facilitates rehabilitation of poststroke aphasic patients | Stroke | 10.1161/01.str.31.9.2112 |
| Rosen et al. | 2000 | Neural correlates of recovery from aphasia after damage to left inferior frontal cortex | Neurology | 10.1212/wnl.55.12.1883 |
| Blasi et al. | 2002 | Word retrieval learning modulates right frontal cortex in patients with left frontal damage | Neuron | 10.1016/s0896-6273(02)00936-4 |
| Leff et al. | 2002 | A physiological change in the homotopic cortex following left posterior temporal lobe infarction | Annals of Neurology | 10.1002/ana.10181 |
| Blank et al. | 2003 | Speech production after stroke: The role of the right pars opercularis | Annals of Neurology | 10.1002/ana.10656 |
| Cardebat et al. | 2003 | Behavioral and neurofunctional changes over time in healthy and aphasic subjects: A PET language activation study | Stroke | 10.1161/01.str.0000099965.99393.83 |
| Sharp et al. | 2004 | Retrieving meaning after temporal lobe infarction: The role of the basal language area | Annals of Neurology | 10.1002/ana.20294 |
| Zahn et al. | 2004 | Recovery of semantic word processing in global aphasia: A functional MRI study | Cognitive Brain Research | 10.1016/j.cogbrainres.2003.10.021 |
| Crinion & Price | 2005 | Right anterior superior temporal activation predicts auditory sentence comprehension following aphasic stroke | Brain | 10.1093/brain/awh659 |
| de Boissezon et al. | 2005 | Subcortical aphasia: A longitudinal PET study | Stroke | 10.1161/01.str.0000169947.08972.4f |
| Connor et al. | 2006 | Cerebellar activity switches hemispheres with cerebral recovery in aphasia | Neuropsychologia | 10.1016/j.neuropsychologia.2005.05.019 |
| Crinion et al. | 2006 | Listening to narrative speech after aphasic stroke: The role of the left anterior temporal lobe | Cerebral Cortex | 10.1093/cercor/bhj053 |
| Saur et al. | 2006 | Dynamics of language reorganization after stroke | Brain | 10.1093/brain/awl090 |
| Meinzer et al. | 2008 | Functional re-recruitment of dysfunctional brain areas predicts language recovery in chronic aphasia | NeuroImage | 10.1016/j.neuroimage.2007.10.008 |
| Raboyeau et al. | 2008 | Right hemisphere activation in recovery from aphasia: Lesion effect or function recruitment? | Neurology | 10.1212/01.wnl.0000287115.85956.87 |
| Richter et al. | 2008 | Association between therapy outcome and right-hemispheric activation in chronic aphasia | Brain | 10.1093/brain/awn043 |
| de Boissezon et al. | 2009 | Good recovery from aphasia is also supported by right basal ganglia: A longitudinal controlled PET study | European Journal of Physical & Rehabilitation Medicine | n/a |
| Fridriksson et al. | 2009 | Cortical mapping of naming errors in aphasia | Human Brain Mapping | 10.1002/hbm.20683 |
| Menke et al. | 2009 | Imaging short- and long-term training success in chronic aphasia | BMC Neuroscience | 10.1186/1471-2202-10-118 |
| Specht et al. | 2009 | Joint independent component analysis of structural and functional images reveals complex patterns of functional reorganisation in stroke aphasia | NeuroImage | 10.1016/j.neuroimage.2009.06.011 |
| Warren et al. | 2009 | Anterior temporal lobe connectivity correlates with functional outcome after aphasic stroke | Brain | 10.1093/brain/awp270 |
| Chau et al. | 2010 | An fMRI study showing the effect of acupuncture in chronic stage stroke patients with aphasia | Journal of Acupuncture and Meridian Studies | 10.1016/s2005-2901(10)60009-x |
| Fridriksson | 2010 | Preservation and modulation of specific left hemisphere regions is vital for treated recovery from anomia in stroke | Journal of Neuroscience | 10.1523/jneurosci.2227-10.2010 |
| Fridriksson et al. | 2010 | Activity in preserved left hemisphere regions predicts anomia severity in aphasia | Cerebral Cortex | 10.1093/cercor/bhp160 |
| Sharp et al. | 2010 | Increased frontoparietal integration after stroke and cognitive recovery | Annals of Neurology | 10.1002/ana.21866 |
| Thompson, den Ouden, Bonakdarpour, Garibaldi, & Parrish | 2010 | Neural plasticity and treatment-induced recovery of sentence processing in agrammatism | Neuropsychologia | 10.1016/j.neuropsychologia.2010.06.036 |
| Tyler et al. | 2010 | Reorganization of syntactic processing following left-hemisphere brain damage: Does right-hemisphere activity preserve function? | Brain | 10.1093/brain/awq262 |
| van Oers et al. | 2010 | Contribution of the left and right inferior frontal gyrus in recovery from aphasia: A functional MRI study in stroke patients with preserved hemodynamic responsiveness | NeuroImage | 10.1016/j.neuroimage.2009.08.057 |
| Papoutsi et al. | 2011 | Is left fronto-temporal connectivity essential for syntax? Effective connectivity, tractography and performance in left-hemisphere damaged patients | NeuroImage | 10.1016/j.neuroimage.2011.06.036 |
| Sebastian & Kiran | 2011 | Task-modulated neural activation patterns in chronic stroke patients with aphasia | Aphasiology | 10.1080/02687038.2011.557436 |
| Szaflarski et al. | 2011 | Excitatory repetitive transcranial magnetic stimulation induces improvements in chronic post-stroke aphasia | Medical Science Monitor | 10.12659/msm.881446 |
| Tyler et al. | 2011 | Left inferior frontal cortex and syntax: Function, structure and behaviour in patients with left hemisphere damage | Brain | 10.1093/brain/awq369 |
| Weiduschat et al. | 2011 | Effects of repetitive transcranial magnetic stimulation in aphasic stroke: A randomized controlled pilot study | Stroke | 10.1161/strokeaha.110.597864 |
| Allendorfer et al. | 2012 | Different patterns of language activation in post-stroke aphasia are detected by overt and covert versions of the verb generation fMRI task | Medical Science Monitor | 10.12659/msm.882518 |
| Fridriksson, Hubbard, et al. | 2012 | Speech entrainment enables patients with Broca’s aphasia to produce fluent speech | Brain | 10.1093/brain/aws301 |
| Fridriksson, Richardson, et al. | 2012 | Left hemisphere plasticity and aphasia recovery | NeuroImage | 10.1016/j.neuroimage.2011.12.057 |
| Marcotte et al. | 2012 | Therapy-induced neuroplasticity in chronic aphasia | Neuropsychologia | 10.1016/j.neuropsychologia.2012.04.001 |
| Schofield et al. | 2012 | Changes in auditory feedback connections determine the severity of speech processing deficits after stroke | Journal of Neuroscience | 10.1523/jneurosci.4670-11.2012 |
| Wright et al. | 2012 | Differentiating hemispheric contributions to syntax and semantics in patients with left-hemisphere lesions | Journal of Neuroscience | 10.1523/jneurosci.0485-12.2012 |
| Szaflarski et al. | 2013 | Recovered vs. not-recovered from post-stroke aphasia: The contributions from the dominant and non-dominant hemispheres | Restorative Neurology and Neuroscience | 10.3233/rnn-120267 |
| Thiel et al. | 2013 | Effects of noninvasive brain stimulation on language networks and recovery in early poststroke aphasia | Stroke | 10.1161/strokeaha.111.000574 |
| Abel et al. | 2014 | Neural underpinnings for model-oriented therapy of aphasic word production | Neuropsychologia | 10.1016/j.neuropsychologia.2014.03.010 |
| Benjamin et al. | 2014 | A behavioral manipulation engages right frontal cortex during aphasia therapy | Neurorehabilitation & Neural Repair | 10.1177/1545968313517754 |
| Brownsett et al. | 2014 | Cognitive control and its impact on recovery from aphasic stroke | Brain | 10.1093/brain/awt289 |
| Mattioli et al. | 2014 | Early aphasia rehabilitation is associated with functional reactivation of the left inferior frontal gyrus: A pilot study | Stroke | 10.1161/strokeaha.113.003192 |
| Mohr, Difrancesco, Harrington, Evans, & Pulvermüller | 2014 | Changes of right-hemispheric activation after constraint-induced, intensive language action therapy in chronic aphasia: fMRI evidence from auditory semantic processing | Frontiers in Human Neuroscience | 10.3389/fnhum.2014.00919 |
| Robson et al. | 2014 | The anterior temporal lobes support residual comprehension in Wernicke’s aphasia | Brain | 10.1093/brain/awt373 |
| Szaflarski et al. | 2014 | Age at stroke determines post-stroke language lateralization | Restorative Neurology & Neuroscience | 10.3233/rnn-140402 |
| van Hees et al. | 2014 | Neural activity associated with semantic versus phonological anomia treatments in aphasia | Brain & Language | 10.1016/j.bandl.2013.12.004 |
| Abel et al. | 2015 | Therapy-induced brain reorganization patterns in aphasia | Brain | 10.1093/brain/awv022 |
| Kiran, Meier, Kapse, & Glynn | 2015 | Changes in task-based effective connectivity in language networks following rehabilitation in post-stroke patients with aphasia | Frontiers in Human Neuroscience | 10.3389/fnhum.2015.00316 |
| Sandberg, Bohland, & Kiran | 2015 | Changes in functional connectivity related to direct training and generalization effects of a word finding treatment in chronic aphasia | Brain & Language | 10.1016/j.bandl.2015.09.002 |
| Geranmayeh et al. | 2016 | Network dysfunction predicts speech production after left hemisphere stroke | Neurology | 10.1212/wnl.0000000000002537 |
| Griffis et al. | 2016 | Interhemispheric plasticity following intermittent theta burst stimulation in chronic poststroke aphasia | Neural Plasticity | 10.1155/2016/4796906 |
| Sims et al. | 2016 | The relationships between the amount of spared tissue, percent signal change, and accuracy in semantic processing in aphasia | Neuropsychologia | 10.1016/j.neuropsychologia.2015.10.019 |
| Darkow et al. | 2017 | Transcranial direct current stimulation effects on neural processing in post-stroke aphasia | Human Brain Mapping | 10.1002/hbm.23469 |
| Geranmayeh et al. | 2017 | Domain-general subregions of the medial prefrontal cortex contribute to recovery of language after stroke | Brain | 10.1093/brain/awx134 |
| Griffis, Nenert, Allendorfer, & Szaflarski | 2017 | Linking left hemispheric tissue preservation to fMRI language task activation in chronic stroke patients | Cortex | 10.1016/j.cortex.2017.08.031 |
| Griffis, Nenert, Allendorfer, Vannest, et al. | 2017 | The canonical semantic network supports residual language function in chronic post-stroke aphasia | Human Brain Mapping | 10.1002/hbm.23476 |
| Harvey et al. | 2017 | Functional reorganization of right prefrontal cortex underlies sustained naming improvements in chronic aphasia via repetitive transcranial magnetic stimulation | Cognitive & Behavioral Neurology | 10.1097/wnn.0000000000000141 |
| Nardo et al. | 2017 | Less is more: Neural mechanisms underlying anomia treatment in chronic aphasic patients | Brain | 10.1093/brain/awx234 |
| Nenert et al. | 2017 | Neuroimaging correlates of post-stroke aphasia rehabilitation in a pilot randomized trial of constraint-induced aphasia therapy | Medical Science Monitor | 10.12659/msm.902301 |
| Qiu et al. | 2017 | Evidence of cortical reorganization of language networks after stroke with subacute Broca’s aphasia: A blood oxygenation level dependent-functional magnetic resonance imaging study | Neural Regeneration Research | 10.4103/1673-5374.198996 |
| Skipper-Kallal et al. | 2017a | Functional activation independently contributes to naming ability and relates to lesion site in post-stroke aphasia | Human Brain Mapping | 10.1002/hbm.23504 |
| Skipper-Kallal et al. | 2017b | Right hemisphere remapping of naming functions depends on lesion size and location in poststroke aphasia | Neural Plasticity | 10.1155/2017/8740353 |
| Dietz et al. | 2018 | The feasibility of improving discourse in people with aphasia through AAC: Clinical and functional MRI correlates | Aphasiology | 10.1080/02687038.2018.1447641 |
| Hallam et al. | 2018 | Task-based and resting-state fMRI reveal compensatory network changes following damage to left inferior frontal gyrus | Cortex | 10.1016/j.cortex.2017.10.004 |
| Nenert et al. | 2018 | Longitudinal fMRI study of language recovery after a left hemispheric ischemic stroke | Restorative Neurology & Neuroscience | 10.3233/rnn-170767 |
| Pillay et al. | 2018 | The neural basis of successful word reading in aphasia | Journal of Cognitive Neuroscience | 10.1162/jocn_a_01214 |
| Szaflarski et al. | 2018 | A feasibility study of combined intermittent theta burst stimulation and modified constraint-induced aphasia therapy in chronic post-stroke aphasia | Restorative Neurology & Neuroscience | 10.3233/rnn-180812 |
| van de Sandt-Koenderman, Orellana, van der Meulen, Smits, & Ribbers | 2018 | Language lateralisation after Melodic Intonation Therapy: An fMRI study in subacute and chronic aphasia | Aphasiology | 10.1080/02687038.2016.1240353 |
| van Oers et al. | 2018 | Etiology of language network changes during recovery of aphasia after stroke | Scientific Reports | 10.1038/s41598-018-19302-4 |
| Barbieri, Mack, Chiappetta, Europa, & Thompson | 2019 | Recovery of offline and online sentence processing in aphasia: Language and domain-general network neuroplasticity | Cortex | 10.1016/j.cortex.2019.06.015 |
| Johnson et al. | 2019 | Treatment-related changes in neural activation vary according to treatment response and extent of spared tissue in patients with chronic aphasia | Cortex | 10.1016/j.cortex.2019.08.016 |
| Kristinsson et al. | 2019 | Brain-derived neurotrophic factor genotype-specific differences in cortical activation in chronic aphasia | Journal of Speech, Language, & Hearing Research | 10.1044/2019_jslhr-l-rsnp-19-0021 |
| Purcell et al. | 2019 | Re-learning to be different: Increased neural differentiation supports post-stroke language recovery | NeuroImage | 10.1016/j.neuroimage.2019.116145 |
| Sreedharan, Chandran, et al. | 2019 | Self-regulation of language areas using real-time functional MRI in stroke patients with expressive aphasia | Brain Imaging & Behavior | 10.1007/s11682-019-00106-7 |
| Hartwigsen et al. | 2020 | Short-term modulation of the lesioned language network | eLife | 10.7554/elife.54277 |
| Stockert et al. | 2020 | Dynamics of language reorganization after left temporo-parietal and frontal stroke | Brain | 10.1093/brain/awaa023 |