Figure 4.

Functional characterization of the sera from COVID-19 individuals

(A) AS (blue; n = 21) and S (red; n = 76) sera were tested with serial dilutions for their ability to neutralize Spike pseudoparticles, neutralize SARS-CoV-2, trigger ADCC in the Jurkat-CD16-NFAT-rLuc/Raji-spike system, or induce CDC of Raji-spike cells. The mean activity at each serum dilution and the 95% confidence interval are depicted.

(B) The half-maximal inhibitory dilution (ID₅₀) of pseudoneutralization and neutralization, and the ED₅₀ of ADCC and CDC induction are depicted. AS (blue; n = 21) and S (red; n = 76) groups are compared.

(C) The maximum activity of each assay is compared for AS (blue; n = 21) and S (red; n = 76) individuals.

∗p < 0.05 (Mann-Whitney test). Dotted lines: positivity threshold measured with pre-pandemic sera. Bars indicate median. See also Table S2.