Figure 6.

Similarity of antibody response in other groups of asymptomatic, symptomatic, and hospitalized individuals

(A) IgG (left), IgA (middle), and IgM (right) levels were quantified in ASs (n = 31), Ss (n = 43), and Hs (n = 21) using the S-Flow assay. The percentage of positive cells is represented.

(B) AS (n = 31), S (n = 43), and H (n = 21) sera were tested for their ability to neutralize spike pseudoparticles (left), trigger ADCC in the Jurkat-CD16-NFAT-rLuc/Raji-spike system (middle), or trigger CDC of Raji-spike cells (right).

(C) Principal component analysis of asymptomatic (blue; n = 31), symptomatic (red; n = 43), and hospitalized (brown; n = 21) patients. Each point represents a single patient. The ellipses indicate the Student’s t-distribution with 95% probability for each group.

Dotted lines: positivity threshold measured with pre-pandemic sera; bars are median. In (A) and (B), a Kruskal-Wallis test was performed; ∗p < 0.05, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001. See also Figures S5–S7 and Tables S3 and S4.