Figure 7.

Kinetics of antibody functions in acute hospitalized patients and convalescent mildly symptomatic individuals

(A) Hospitalized patients (n = 7) in the acute phase were sampled at several times after symptom onset. Their IgG (top left), IgM (top middle), and IgA (top right) levels were assessed longitudinally. CDC (bottom left), ADCC (bottom middle), and pseudoneutralization (bottom right) were also measured. The red curve represents a non-linear fit (four parameters) of the mean of all donors. The average fit of each function is also depicted (right panel).

(B) Sera from mildly symptomatic patients in the convalescent phase (n = 21–22) were sampled twice at a 25–29-day interval. ADCC (top left), IgG (top right), pseudoneutralization (middle left), real-virus neutralization (middle right), and CDC (bottom left) levels were measured with serial dilutions. For each assay, the ED₅₀ is represented against the day after symptom onset on the left graph. On the right graph, data for first and second samplings were pooled. ∗p < 0.05, ∗∗p < 0.01, ns, not significant (Wilcoxon test).

See also Table S4.