Table 3.
Characteristics of patients with DFI in different grades of Meggitt Wagner’s and IDSA/IWGDF
| Parameters | Meggitt Wagner’s grade | p value | IDSA/IWGDF infection severity | p value | ||||
|---|---|---|---|---|---|---|---|---|
| Grade 2 | Grade 3 | Grade 4 | Mild | Moderate | Severe | |||
| No of patients (n=120) | 30 (25%) | 60 (50%) | 30 (25%) | 30 (25%) | 48 (40%) | 42 (35%) | ||
| Clinical and laboratory characteristics | ||||||||
| Age (years) | 50.1±9.9 | 58.2±8.35 | 57.73±10.8 | 0.051 | 51.8±11.2 | 59.7± 8.3 | 54.9±9.4 | 0.037 |
| BMI | 29.1±0.35 | 29.7±5.7 | 28.63±5.7 | 0.908 | 30±5.9 | 28.3±5.9 | 29.7±5.8 | 0.619 |
| SBP | 131.3±18 | 138.3±16.6 | 134±15.4 | 0.391 | 131.3±17.3 | 137.5±15.4 | 136.2±18.0 | 0.568 |
| DBP | 84.6±10.6 | 86±9.6 | 84.6±9.9 | 0.923 | 84±9.8 | 87.1±9.5 | 84.3±10.3 | 0.643 |
| Duration of DM (years) | 12.9±4.18 | 13.9±6.9 | 17.4±6.6 | 0.127 | 14±5.5 | 13.5±5.4 | 16.2±7.9 | 0.346 |
| HbA1c (%) | 10.2±2.02 | 9.8±2.05 | 11.44±2.1 | 0.053 | 10.3±1.9 | 10±2.3 | 10.8±2.1 | 0.494 |
| Fasting blood glucose (mg/dL) | 254.8±80.7 | 273.1±81.1 | 296.8±74.8 | 0.356 | 273.7±82.1 | 273.7±82.1 | 279.9±77.9 | 0.968 |
| Serum creatinine (mg/dL) | 1.4±1.3 | 0.9±0.3 | 0.9±0.3 | 0.062 | 1.4±1.3 | 0.9±0.3 | 0.9±0.3 | 0.015 |
| eGFR | 49.2±30.0 | 55.9±19.8 | 50.4±23.1 | 0.237 | 45.7±29.3 | 52.9±20.0 | 57.9±21.9 | 0.053 |
| UACR | 41.9±23.3 | 42.3±18.4 | 41.6±20.1 | 0.853 | 42.9±24.2 | 40.8±16.3 | 43±21.3 | 0.956 |
| CRP (mg/dL) | 25.1±21.5 | 84.9±61.5 | 123.5±80.9 | <0.001 | 30±25.1 | 68.9±38.7 | 127.4±87.03 | <0.001 |
| TLC (g/L) | 98.4±4.6 | 97.2±4.1 | 98.7±5.02 | 0.312 | 98±4.4 | 98.3±4.2 | 97.5±5.0 | 0.956 |
| ANC (g/L) | 68.6±8.3 | 76.9±9.4 | 81±6.19 | 0.001 | 70.2±10.1 | 76.9±8.9 | 78.7±8.4 | 0.021 |
| Diabetic foot characteristics | ||||||||
| Reflexes (intact) | 28 (93.3%) | 36 (60%) | 20 (66.7%) | 0.070 | 24 (80%) | 36 (75%) | 24 (57.1%) | 0.265 |
| Presence of callosities | 26 (86.7%) | 26 (43.3%) | 14 (46.7%) | 0.017 | 26 (86.7%) | 26 (54.2%) | 14 (33.3%) | 0.007 |
| Presence of inter-digital infection | 14 (46.7%) | 36 (60%) | 18 (60%) | 0.665 | 14 (46.7%) | 28 (58.3%) | 26 (61.9%) | 0.646 |
| Microbiological data | ||||||||
| Type of infection (n=98) | ||||||||
| Monomicrobial (n=56) | 12 (40%) | 24 (40%) | 20 (66.7%) | 0.420 | 10 (33.3%) | 22 (45.8%) | 24 (57.1%) | 0.756 |
| Polymicrobial (n=42) | 12 (40%) | 20 (33.3%) | 10 (33.3%) | 10 (33.3%) | 16 (33.3%) | 16 (38.1%) | ||
| Aerobic bacteria (n=124) | ||||||||
| Gram-positive (n=26) | 12 | 10 | 4 | 0.063 | 12 | 8 | 6 | 0.010 |
| Gram-negative (n=98) | 24 | 42 | 32 | 18 | 36 | 44 | ||
| Anaerobic bacteria (n=120) | ||||||||
| Present (n=26) | 6 | 14 | 6 | 0.906 | 4 | 12 | 10 | 0.437 |
| Absent (n=94) | 24 | 46 | 24 | 26 | 36 | 32 | ||
Data is presented as mean±SD or n (%).
BMI – body mass index; SBP – systolic blood pressure; DBP – diastolic blood pressure; DM – diabetes mellitus; HbA1c – glycosylated hemoglobin; eGFR – estimated glomerular filtration rate; UACR – urinary albumin creatinine ratio; CRP – C-reactive protein; TLC – total leucocyte count; ANC – absolute neutrophil count.