. Author manuscript; available in PMC: 2021 Apr 20.

Published in final edited form as: J Alzheimers Dis. 2021;79(2):895–903. doi: 10.3233/JAD-201267

Table 2.

Plasma metabolites altered between D-CAA mutation non-carriers and carriers.

	D-CAA NC		D-CAA MC		p	p^a	p^b	p^c
*Biogenic amines*	Mean	SD	Mean	SD
Spermidine	0.159	0.038	0.082	0.038	0.001	0.001	0.001	0.0001
SDMA	0.523	0.065	0.419	0.046	0.002	0.002	0.003	0.005
*Amino acids*
Phenylalanine	62.475	6.635	54.133	3.291	0.004	0.006	0.007	0.011
Tryptophan	65.463	12.288	54.956	7.003	0.044	0.022	0.022	0.035
*Sum of hexoses*
Hexoses	7999.5	983.656	6980.333	583.862	0.019	0.019	0.006	0.008
*Acylcarnitines*
AC(4:0)	0.397	0.127	0.286	0.124	0.089	0.076	0.083	0.041
AC(5:0)	3.958	0.966	2.893	0.761	0.023	0.021	0.026	0.040
AC(14:0)	0.026	0.005	0.019	0.006	0.015	0.019	0.023	0.006
AC(16:0)	0.080	0.019	0.063	0.011	0.033	0.035	0.043	0.049
Composite AC score	0.532	0.474	−0.473	0.538	0.001	0.001	0.002	0.001
*Sphingolipids*
SM(30:1)	0.845	0.240	0.648	0.206	0.089	0.050	0.024	0.021
SM(32:2)	1.261	0.441	0.887	0.242	0.044	0.047	0.018	0.007
SM(34:2)	17.838	3.920	15.078	3.486	0.145	0.127	0.063	0.042
SM(35:1)	4.895	0.600	4.077	1.205	0.103	0.097	0.065	0.041
SM(36:1)	53.663	10.127	41.456	10.332	0.027	0.033	0.024	0.007
SM(36:2)	8.201	1.603	6.891	1.690	0.123	0.138	0.056	0.016
SM(37:1)	4.389	0.816	3.586	1.067	0.105	0.121	0.076	0.014
SM(38:2)	11.311	2.861	9.199	2.449	0.122	0.121	0.105	0.033
SM(40:2)	34.4	9.455	26.342	9.227	0.096	0.087	0.076	0.040
SM(42:1)	24.925	5.170	20.289	5.060	0.082	0.084	0.094	0.034
SM(42:2)	70.613	13.924	58.844	14.689	0.112	0.116	0.093	0.048
SM(44:2)	1.675	0.279	1.287	0.341	0.022	0.028	0.021	0.017
Composite SM score	0.447	0.697	−0.398	0.781	0.033	0.037	0.018	0.004
*Phospholipids*
PC-O(42:4)	0.621	0.275	0.368	0.157	0.032	0.028	0.018	0.024

Metabolites measured in the plasma were compared between D-CAA mutation non-carriers (D-CAA NCs, n=8) and pre-symptomatic mutation carriers (D-CAA MCs, n=9) employing linear models. p^a indicates p-values adjusted for age; p^b indicates p values adjusted for age and sex; p^c indicates p values adjusted for age, sex and APOE ε4 status. Only metabolites with p^c<0.05 have been presented in the current table and were considered as statistically significant. All metabolite concentrations are presented in μM. SDMA, symmetric dimethyl arginine; PC-O, phospholipid with choline headgroup and presence of an alkyl ether substituent.