Table 2.
Distributions of IL-9 and IL-10 SNP genotypes and alleles in the early, exudative, and atrophic AMD and control groups.
| SNP | Genotypes/alleles | Group | p value∗ | p value∗∗ | p value∗∗∗ | |||
|---|---|---|---|---|---|---|---|---|
| Early AMD (n = 343), n (%) | Exudative AMD (n = 422), n (%) | Atrophic AMD (n = 61), n (%) | Control (n = 383), n (%) | |||||
| IL-9 rs1859430 | GG | 225 (65.6) | 262 (62.1) | 33 (54.1) | 233 (60.8) | 0.024 | 0.871 | 0.426 |
| GA | 95 (27.7) | 143 (33.9) | 24 (39.3) | 136 (35.5) | ||||
| AA | 23 (6.7) | 17 (4.0) | 4 (6.6) | 14 (3.7) | ||||
| G | 545 (79.4) | 667 (79.0) | 90 (73.8) | 602 (78.6) | 0.625 | 0.472 | 0.088 | |
| A | 141 (20.6) | 177 (21.0) | 32 (26.2) | 146 (21.4) | ||||
|
| ||||||||
| IL-9 rs2069870 | AA | 222 (64.7) | 262 (62.1) | 33 (54.1) | 235 (61.4) | 0.349 | 0.832 | 0.282 |
| AG | 121 (35.3) | 160 (37.9) | 28 (45.9) | 148 (38.6) | ||||
| GG | 0 (0) | 0 (0) | 0 (0) | 0 (0) | ||||
| A | 565 (82.4) | 684 (81.0) | 94 (77.0) | 618 (80.7) | 0.410 | 0.853 | 0.350 | |
| G | 121 (17.6) | 160 (19.0) | 28 (23.0) | 148 (19.3) | ||||
|
| ||||||||
| IL-9 rs11741137 | CC | 238 (69.4) | 290 (68.7) | 41 (67.2) | 247 (64.5) | 0.117 | 0.389 | 0.846 |
| CT | 91 (26.5) | 120 (28.6) | 18 (29.5) | 126 (32.9) | ||||
| TT | 14 (4.1) | 12 (2.8) | 2 (3.3) | 10 (2.6) | ||||
| C | 657 (82.7) | 700 (82.9) | 100 (82.0) | 620 (80.9) | 0.053 | 0.297 | 0.788 | |
| T | 119 (17.3) | 144 (17.1) | 22 (18.0) | 146 (19.1) | ||||
|
| ||||||||
| IL-9 rs2069885 | GG | 240 (70.0) | 293 (69.4) | 41 (67.2) | 250 (65.3) | 0.172 | 0.453 | 0.892 |
| GA | 90 (26.2) | 119 (28.2) | 18 (29.5) | 123 (32.1) | ||||
| AA | 13 (3.8) | 10 (2.4) | 2 (3.3) | 10 (2.6) | ||||
| G | 570 (83.1) | 705 (83.5) | 100 (82.0) | 623 (81.3) | 0.382 | 0.24 | 60.867 | |
| A | 116 (16.9) | 139 (16.5) | 22 (18.0) | 143 (18.7) | ||||
|
| ||||||||
| IL-9 rs2069884 | GG | 239 (69.7) | 292 (69.2) | 41 (67.2) | 250 (65.3) | 0.199 | 0.495 | 0.892 |
| GT | 91 (26.5) | 120 (28.4) | 18 (29.5) | 123 (32.1) | ||||
| TT | 13 (3.8) | 10 (2.4) | 2 (3.3) | 10 (2.6) | ||||
| G | 569 (82.9) | 704 (83.4) | 100 (82.0) | 623 (81.3) | 0.424 | 0.273 | 0.867 | |
| T | 117 (17.1) | 140 (16.6) | 22 (18.0) | 143 (18.7) | ||||
|
| ||||||||
| IL-10 rs1800871 | GG | 208 (60.6) | 252 (59.7) | 38 (62.3) | 232 (60.6) | 0.705 | 0.903 | 0.957 |
| GA | 123 (35.9) | 152 (36.0) | 20 (32.8) | 133 (34.7) | ||||
| AA | 12 (3.5) | 18 (4.3) | 3 (4.9) | 18 (4.7) | ||||
| G | 539 (78.6) | 656 (77.7) | 96 (78.7) | 597 (77.9) | 0.770 | 0.918 | 0.852 | |
| A | 147 (21.4) | 188 (22.3) | 26 (21.3) | 169 (22.1) | ||||
|
| ||||||||
| IL-10 rs1800872 | GG | 208 (60.6) | 252 (59.7) | 38 (62.3) | 232 (60.6) | 0.705 | 0.903 | 0.957 |
| GT | 123 (35.9) | 152 (36.0) | 20 (32.8) | 133 (34.7) | ||||
| TT | 12 (3.5) | 18 (4.3) | 3 (4.9) | 18 (4.7) | ||||
| G | 539 (78.6) | 656 (77.7) | 96 (78.7) | 597 (77.9) | 0.770 | 0.918 | 0.852 | |
| T | 147 (21.4) | 188 (22.3) | 26 (21.3) | 169 (22.1) | ||||
|
| ||||||||
| IL-10 rs1800896 | TT | 103 (30.0) | 112 (26.5) | 14 (23.0) | 103 (26.9) | 0.642 | 0.319 | 0.084 |
| TC | 175 (51.0) | 207 (49.1) | 27 (44.3) | 203 (53.0) | ||||
| CC | 65 (19.0) | 103 (24.4) | 20 (32.8) | 77 (20.1) | ||||
| T | 381 (55.5) | 431 (51.1) | 55 (45.1) | 409 (53.4) | ||||
| C | 305 (44.5) | 413 (48.9) | 67 (54.9) | 357 (46.6) | 0.413 | 0.350 | 0.088 | |
∗Early AMD vs. control group. ∗∗Exudative AMD vs. control group. ∗∗∗Atrophic AMD vs. control group. p: significance level and Bonferroni corrected significance level when p = 0.05/8.