Table 2.
Hippocampal subfield volume difference between healthy controls, patient controls, and suicide attempters with MDD.
| Subfields | HC (n = 37) | PC (n = 27) | SA (n = 40) | F | P | P FDR | HC vs. PC | HC vs. SA | PC vs SA |
|---|---|---|---|---|---|---|---|---|---|
| Left whole | 3298.54 ± 302.50 | 3322.77 ± 278.58 | 3290.71 ± 321.39 | ||||||
| Left hippocampal tail | 532.70 ± 77.41 | 536.28 ± 90.47 | 546.15 ± 64.26 | 0.426 | 0.654 | 1.000 | 1.000 | 1.000 | 1.000 |
| Left subiculum | 420.03 ± 41.75 | 422.15 ± 39.41 | 418.21 ± 48.58 | 0.197 | 0.822 | 1.000 | 1.000 | 1.000 | 1.000 |
| Left CA1 | 598.25 ± 63.63 | 602.20 ± 57.48 | 591.35 ± 70.84 | 0.395 | 0.675 | 1.000 | 1.000 | 1.000 | 1.000 |
| Left hippocampal fissure | 147.61 ± 23.23 | 127.46 ± 17.03 | 147.34 ± 26.43 | 7.900 | 0.001∗ | 0.012∗ | 0.002 | 1.000 | 0.001 |
| Left presubiculum | 310.00 ± 34.21 | 302.90 ± 29.24 | 307.90 ± 37.79 | 0.293 | 0.747 | 1.000 | 1.000 | 1.000 | 1.000 |
| Left parasubiculum | 66.26 ± 12.10 | 64.68 ± 10.76 | 62.17 ± 9.40 | 1.585 | 0.210 | 1.000 | 1.000 | 0.258 | 0.787 |
| Left molecular-layer-HP | 538.95 ± 49.98 | 542.05 ± 46.33 | 534.51 ± 57.16 | 0.422 | 0.657 | 1.000 | 1.000 | 1.000 | 1.000 |
| Left GC-ML-DG | 278.40 ± 36.04 | 283.67 ± 29.72 | 277.50 ± 34.13 | 0.735 | 0.482 | 1.000 | 0.763 | 1.000 | 0.963 |
| Left CA3 | 176.21 ± 25.92 | 181.02 ± 25.10 | 180.48 ± 27.26 | 0.718 | 0.490 | 1.000 | 0.839 | 1.000 | 1.000 |
| Left CA4 | 237.83 ± 30.98 | 242.58 ± 25.88 | 237.38 ± 28.16 | 0.740 | 0.480 | 1.000 | 0.751 | 1.000 | 0.974 |
| Left fimbria | 88.00 ± 21.70 | 93.91 ± 16.24 | 84.61 ± 24.09 | 3.319 | 0.004∗ | 0.032∗ | 0.436 | 1.000 | 0.181 |
| Left HATA | 51.93 ± 8.77 | 51.33 ± 7.29 | 50.43 ± 7.38 | 0.344 | 0.709 | 1.000 | 1.000 | 1.000 | 1.000 |
| Right whole | 3427.53 ± 344.82 | 3412.03 ± 306.43 | 3427.53 ± 336.36 | ||||||
| Right hippocampal tail | 549.32 ± 65.18 | 540.73 ± 81.40 | 562.13 ± 83.83 | 0.835 | 0.437 | 1.000 | 1.000 | 1.000 | 0.738 |
| Right subiculum | 429.82 ± 44.40 | 425.51 ± 45.34 | 427.14 ± 46.62 | 0.012 | 0.988 | 1.000 | 1.000 | 1.000 | 0.705 |
| Right CA1 | 645.82 ± 74.76 | 631.60 ± 78.42 | 638.65 ± 73.12 | 0.129 | 0.879 | 1.000 | 1.000 | 1.000 | 1.000 |
| Right hippocampal fissure | 161.00 ± 20.45 | 140.28 ± 20.02 | 159.82 ± 23.88 | 9.161 | <0.001∗∗ | <0.001∗∗ | 0.001 | 1.000 | 0.001 |
| Right presubiculum | 297.08 ± 37.50 | 287.48 ± 32.00 | 289.91 ± 36.35 | 0.452 | 0.638 | 1.000 | 1.000 | 1.000 | 1.000 |
| Right parasubiculum | 63.76 ± 10.53 | 59.06 ± 9.61 | 60.09 ± 9.08 | 1.791 | 0.172 | 1.000 | 0.287 | 0.375 | 1.000 |
| Right molecular-layer-HP | 565.99 ± 58.58 | 564.33 ± 57.26 | 561.18 ± 58.51 | 0.082 | 0.922 | 0.998 | 1.000 | 1.000 | 1.000 |
| Right GC-ML-DG | 290.48 ± 38.07 | 297.93 ± 32.41 | 293.75 ± 34.72 | 0.983 | 0.378 | 1.000 | 0.496 | 1.000 | 1.000 |
| Right CA3 | 192.22 ± 29.22 | 201.42 ± 27.09 | 199.86 ± 28.41 | 1.762 | 0.177 | 1.000 | 0.269 | 0.431 | 1.000 |
| Right CA4 | 248.70 ± 31.54 | 256.30 ± 27.65 | 251.53 ± 30.18 | 1.238 | 0.295 | 1.000 | 0.356 | 1.000 | 1.000 |
| Right fimbria | 89.77 ± 22.89 | 95.30 ± 16.73 | 88.92 ± 20.14 | 3.108 | 0.007∗ | 0.042∗ | 0.459 | 1.000 | 0.342 |
| Right HATA | 54.57 ± 7.75 | 52.37 ± 6.20 | 54.37 ± 9.26 | 0.592 | 0.555 | 1.000 | 0.974 | 1.000 | 1.000 |
aBonferroni corrected for multiple comparisons between the groups. ∗P < 0.05, ∗∗P < 0.001. Abbreviations: SA: suicide attempters; PC: patient controls; HC: healthy controls; CA: cornu ammonis; GC-DG: granule cell layer of dentate gyrus; HATA: hippocampus-amygdala transition area; FDR: false discovery rate.