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. 2020 Aug 29;28(3):279–293. doi: 10.1038/s41417-020-00218-z

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© The Author(s), under exclusive licence to Springer Nature America, Inc. 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — During PTC development, overexpressed has_circ_102002 sponged miR-488-3p, upregulated HAS2 expression and promoted the phosphorylation of FAK and Akt. After that, EMT and cell migration-associated genes were regulated, which ultimately facilitated the tumor metastasis.