Table 3.

Summary of cell-specific knockout mouse models used in skin studies

Cell type	Promoter for Cre recombinase	Target	Functions	Study
Keratinocyte knockout	Keratin 5	Keratinocyte in cutaneous wound healing	Modulating epidermal migration, inhibit re-epithelization	[23]
Fibroblast knockout	FSP1	Stromal fibroblast in prostate	Increased apoptosis, decreased epithelial proliferation and collagen composition	[51, 52]
	FSP1	Fibroblast in cutaneous wound healing	Modulating epidermal migration, promote re-epithelization	[23]
Myeloid cell knockout	Lysozyme M	Macrophage	Up-regulate IL-6 and TNF-α production, prolong inflammation	[23]

FSP1 fibroblast-specific protein1, TNF-α tumor necrosis factor-α, IL-6 interleukin-6