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. 2021 Apr 20;12:2335. doi: 10.1038/s41467-021-22531-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Bar plot showing the top 10 significantly enriched upregulated and downregulated pathways in tumours from Apc vs Apc Rac1b mice. B GSEA plots of WNT target gene sets comparing tumours from Apc vs Apc Rac1b mice. C Heatmap of RNAseq expression values of WNT target genes and intestinal stem cell markers comparing tumours from Apc vs Apc Rac1b mice. D qRT-PCR analysis of various WNT target genes comparing tumours from Apc vs Apc Rac1b mice. As controls, matched normal tissue from these mice (WT and Rac1b, respectively) are also included (data are presented as mean ± SD; two-tailed t-test; n = 6v6 mice). Source data are provided as a Source Data file.