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. 2021 Apr 20;7:38. doi: 10.1038/s41522-021-00207-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — The compositions of Akkermansis and uncultured Eubacterium WCHB1-41_ge are the key factors that influence arginine biosynthesis and fatty acid biosynthesis and were significantly higher during the cold season. These microbiota may contribute to energy production during cold season, which is the period of insufficient dietary and protein intake. All enzymes and EC (Enzyme Nomenclature) numbers were obtained from Kyoto Encyclopedia of Genes and Genomes (KEGG) database.