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. 2021 Apr 20;12:2330. doi: 10.1038/s41467-021-22431-6

Fig. 7. Distinct roles of prostaglandin in the regulation of peripheral glucose metabolism.

Fig. 7

In RCD-fed mice, a glucose injection activates cPLA2 in the VMH, which increases the production of prostaglandins from neurons. The increase in prostaglandins is critical for the activation of dmVMH and glucose metabolism in peripheral tissues. Chronic HFD feeding also increases the cPLA2-mediated prostaglandin production from VMH neurons. The chronic effect of prostaglandin enhances hypothalamic inflammation and thus impairs peripheral glucose metabolism.