Table 1.

Cytokine stress and resilience profiles from linear discriminant analysis (LDA)

“Stress” LDA Profile			“Resilience” LDA Profile
Cytokine	r-value	P-value	Cytokine	r-value	P-value
G-CSF	0.617	0.003	G-CSF	0.647	0.002
IL-13	0.586	0.005	Leptin	0.473	0.03
GM-CSF	0.561	0.008	IL-13	0.467	0.033
IL-6	0.470	0.032	TNFα	0.413
IL-17A	0.468	0.032	RANTES	0.382
Leptin	0.467	0.033	IL-17A	0.350
IL-4	0.451	0.04	IL-6	0.348
TNFα	0.406		Eotaxin	0.343
IL-5	0.394		GM-CSF	0.337
IP-10	0.373		IP-10	0.310
MIP2	0.330		MIP-2	0.309
Eotaxin	0.305		EGF	0.306
EGF	0.291		IL-4	0.219
IL-1β	0.273		IL-12p70	0.219
MCP1	0.198		IL-1α	0.211
IL-10	0.186		LIX	0.197
IL-1α	0.166		MCP-1	0.185
IL-12p70	0.138		Fractalkine	0.156
RANTES	0.111		IL-5	0.120
LIX	0.110		VEGF	0.116
VEGF	0.051		IL-1β	0.033
Fractalkine	0.050		IL-10	−0.007
MIP-1α	0.009		IL-18	−0.007
IL-18	0.031		MIP-1α	−0.011
IL-2	0.079		IL-2	−0.149

Note: Values show the strength of correlation (Pearson’s r) of each cytokine to separate LDA functions that discriminated male rats according to either their Stress history (left) or drinking-Resilience (right). Significant correlations (“loadings”) are indicated with their corresponding P-values. Note that significance vs. non-significance shown for a given cytokine (vs. P<0.05) was the same whether calculated within the LDA from each individual cytokine’s Wilks’ lambda or externally as the correlation of the cytokine to the discriminant function score. Stress LDA scores differed significantly across stress groups with NOV>FAM>CTL. Drinking-Resilience associated with significantly higher Resilience LDA scores. See text and Fig.4 for univariate group differences for the significantly predictive cytokines (shown in bold). n=21 male rats.