TABLE 2.
Kaplan-Meier Estimates of 2-, 5-, and 10-Year Unadjusted Survival Probabilities of Patients With Oropharyngeal Cancer Who Survived at Least 5 Years After Diagnosis
| Survival Probability (95% CI) |
|||
|---|---|---|---|
| Subgroup | 2 y | 5 y | 10 y |
| Full study population | 0.94 (0.93–0.95) | 0.83 (0.81–0.85) | 0.63 (0.60–0.67) |
| Age at diagnosis, y | |||
| <55 | 0.97 (0.94–0.98) | 0.91 (0.87–0.93) | 0.80 (0.74–0.84) |
| ≥55 | 0.93 (0.92–0.95) | 0.81 (0.78–0.83) | 0.57 (0.53–0.61) |
| Period of diagnosis | |||
| 2000–2013 | 0.96 (0.95–0.97) | 0.87 (0.85–0.89) | 0.67 (0.62–0.71) |
| 1990–1999 | 0.92 (0.88–0.94) | 0.78 (0.73–0.82) | 0.58 (0.52–0.63) |
| 1980–1989 | 0.86 (0.79–0.91) | 0.70 (0.62–0.77) | 0.54 (0.45–0.62) |
| Sex | |||
| Male | 0.94 (0.93–0.96) | 0.84 (0.82–0.86) | 0.64 (0.60–0.68) |
| Female | 0.93 (0.90–0.96) | 0.80 (0.75–0.85) | 0.60 (0.53–0.67) |
| Smoking status | |||
| Never | 0.97 (0.95–0.98) | 0.92 (0.89–0.94) | 0.76 (0.71–0.80) |
| Former | 0.95 (0.93–0.97) | 0.81 (0.77–0.85) | 0.61 (0.55–0.67) |
| Current | 0.88 (0.85–0.91) | 0.71 (0.66–0.76) | 0.47 (0.41–0.54) |
| Smoking, pack-y | |||
| >10 | 0.91 (0.88–0.93) | 0.74 (0.70–0.77) | 0.50 (0.45–0.55) |
| ≤10 | 0.97 (0.95–0.98) | 0.91 (0.89–0.93) | 0.75 (0.71–0.79) |
| Site | |||
| Tonsil | 0.94 (0.92–0.95) | 0.84 (0.80–0.86) | 0.64 (0.59–0.68) |
| Base of tongue | 0.95 (0.94–0.97) | 0.86 (0.83–0.89) | 0.69 (0.64–0.73) |
| Other | 0.87 (0.78–0.92) | 0.63 (0.52–0.72) | 0.34 (0.24–0.45) |
| T category | |||
| T1 | 0.96 (0.94–0.98) | 0.89 (0.85–0.92) | 0.71 (0.65–0.77) |
| T2 | 0.94 (0.92–0.96) | 0.85 (0.81–0.88) | 0.69 (0.64–0.74) |
| T3 | 0.93 (0.90–0.96) | 0.79 (0.74–0.83) | 0.53 (0.46–0.60) |
| T4 | 0.91 (0.86–0.95) | 0.72 (0.63–0.79) | 0.43 (0.32–0.53) |
| N category (AJCC 7th ed.) | |||
| N0 | 0.88 (0.83–0.92) | 0.71 (0.64–0.77) | 0.51 (0.43–0.58) |
| N1 | 0.94 (0.90–0.96) | 0.84 (0.79–0.88) | 0.64 (0.57–0.71) |
| N2 | 0.96 (0.95–0.97) | 0.87 (0.84–0.89) | 0.67 (0.62–0.71) |
| N3 | 0.88 (0.79–0.93) | 0.75 (0.65–0.83) | 0.56 (0.44–0.67) |
| Neck dissection | |||
| No | 0.94 (0.92–0.95) | 0.82 (0.80–0.85) | 0.62 (0.58–0.65) |
| Yes | 0.95 (0.92–0.97) | 0.86 (0.82–0.89) | 0.69 (0.63–0.75) |
| IMRT | |||
| No | 0.91 (0.88–0.93) | 0.77 (0.73–0.80) | 0.58 (0.53–0.61) |
| Yes | 0.97 (0.95–0.98) | 0.89 (0.86–0.91) | 0.69 (0.62–0.75) |
| Radiation dose, Gy | |||
| >70 | 0.93 (0.90–0.95) | 0.80 (0.76–0.83) | 0.58 (0.53–0.63) |
| >66–70 | 0.92 (0.90–0.94) | 0.80 (0.75–0.83) | 0.60 (0.53–0.65) |
| ≤66 | 0.97 (0.95–0.98) | 0.90 (0.87–0.92) | 0.72 (0.65–0.77) |
| Chemotherapy | |||
| None | 0.93 (0.91–0.95) | 0.81 (0.78–0.84) | 0.63 (0.59–0.67) |
| Adjuvant only | 0.96 (0.92–0.98) | 0.89 (0.84–0.93) | 0.71 (0.62–0.79) |
| Concurrent only | 0.94 (0.91–0.96) | 0.83 (0.79–0.87) | 0.58 (0.50–0.65) |
| Both | 0.97 (0.93–0.98) | 0.88 (0.81–0.93) | 0.61 (0.39–0.77) |
Abbreviations: AJCC, American Joint Committee on Cancer; IMRT, intensity-modulated radiation therapy.