TABLE 4.
Standardized Mortality Ratio Estimates for All-Cause Death of Patients With Oropharyngeal Cancer Who Survived at Least 5 Years After Diagnosis
| Subgroup | No. of Patients | Total Person-Years | No. of Observed Deaths | No. of Expected Deaths | SMR (95% CI) | P |
|---|---|---|---|---|---|---|
| Full study population | 1699 | 10,671.05 | 496 | 125.67 | 3.95 (3.60–4.29) | <.0001 |
| HPV status | ||||||
| Negative | 48 | 176.40 | 4 | 2.04 | 1.96 (0.04–3.88) | .3277 |
| Positive | 429 | 941.34 | 21 | 11.45 | 1.83 (1.05–2.62) | .0372 |
| Period of diagnosis | ||||||
| 1980–1989 | 133 | 1531.88 | 112 | 20.10 | 5.57 (4.54–6.60) | <.0001 |
| 1990–1999 | 311 | 3171.69 | 186 | 36.80 | 5.05 (4.33–5.78) | <.0001 |
| 2000–2013 | 1255 | 5967.48 | 198 | 68.77 | 2.88 (2.48–3.28) | <.0001 |
| Age at diagnosis, y | ||||||
| <55 | 401 | 3201.20 | 81 | 13.01 | 6.23 (4.87–7.58) | <.0001 |
| ≥55 | 1298 | 7469.85 | 415 | 112.66 | 3.68 (3.33–4.04) | <.0001 |
| Sex | ||||||
| Male | 1407 | 8625.97 | 377 | 102.67 | 3.67 (3.30–4.04) | <.0001 |
| Female | 292 | 2045.08 | 119 | 23.00 | 5.17 (4.24–6.10) | <.0001 |
| Smoking status | ||||||
| Never | 744 | 4692.57 | 136 | 49.37 | 2.75 (2.29–3.22) | <.0001 |
| Former | 571 | 3514.43 | 163 | 49.64 | 3.28 (2.78–3.79) | <.0001 |
| Current | 370 | 2411.98 | 194 | 26.10 | 7.43 (6.39–8.48) | <.0001 |
| Smoking, pack-y | ||||||
| >10 | 680 | 4220.84 | 292 | 54.09 | 5.40 (4.78–6.02) | <.0001 |
| ≤10 | 956 | 5913.59 | 171 | 62.47 | 2.74 (2.33–3.15) | <.0001 |
| Site | ||||||
| Tonsil | 773 | 4781.10 | 230 | 52.39 | 4.39 (3.82–4.96) | <.0001 |
| Base of tongue | 821 | 5184.03 | 194 | 62.65 | 3.10 (2.66–3.53) | <.0001 |
| Other | 105 | 705.92 | 72 | 10.63 | 6.77 (5.21–8.34) | <.0001 |
| T category | ||||||
| T1 | 523 | 3132.47 | 98 | 34.35 | 2.85 (2.29–3.42) | <.0001 |
| T2 | 639 | 4158.36 | 173 | 46.77 | 3.70 (3.15–4.25) | <.0001 |
| T3 | 353 | 2346.27 | 151 | 31.02 | 4.87 (4.09–5.64) | <.0001 |
| T4 | 183 | 1006.48 | 73 | 13.44 | 5.43 (4.18–6.68) | <.0001 |
| N category (AJCC 7th ed.) | ||||||
| N0 | 218 | 1621.86 | 124 | 25.49 | 4.86 (4.01–5.72) | <.0001 |
| N1 | 330 | 2388.96 | 101 | 27.45 | 3.68 (2.96–4.40) | <.0001 |
| N2 | 1045 | 5934.37 | 228 | 66.24 | 3.44 (3.00–3.89) | <.0001 |
| N3 | 105 | 698.39 | 42 | 6.41 | 6.56 (4.57–8.54) | <.0001 |
| Neck dissection | ||||||
| No | 1306 | 7966.37 | 387 | 97.50 | 3.97 (3.57–4.36) | <.0001 |
| Yes | 393 | 2704.67 | 109 | 28.17 | 3.87 (3.14–4.60) | <.0001 |
| IMRT | ||||||
| No | 621 | 6086.91 | 369 | 71.38 | 5.17 (4.64–5.70) | <.0001 |
| Yes | 1078 | 4584.13 | 127 | 54.30 | 2.34 (1.93–2.75) | <.0001 |
| Radiation dose, Gy | ||||||
| >70 | 440 | 3918.13 | 222 | 44.69 | 4.97 (4.31–5.62) | <.0001 |
| >66–70 | 622 | 3057.03 | 169 | 38.40 | 4.40 (3.74–5.07) | <.0001 |
| ≤66 | 633 | 3643.70 | 102 | 41.89 | 2.43 (1.96–2.91) | <.0001 |
| Chemotherapy | ||||||
| No | 726 | 5989.76 | 301 | 72.29 | 4.16 (3.69–4.63) | <.0001 |
| Yes | 973 | 4681.29 | 195 | 53.38 | 3.65 (3.14–4.17) | <.0001 |
Abbreviations: AJCC, American Joint Committee on Cancer; HPV, human papillomavirus; IMRT, intensity-modulated radiation therapy; SMR, standardized mortality ratio.