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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Curr Opin Cell Biol. 2021 Feb 4;69:96–102. doi: 10.1016/j.ceb.2020.11.008

Figure 1. Negative feedback loops lead to desensitization.

Figure 1.

(a) Topology of a general negative feedback loop. (b) An example of negative feedback system that causes desensitization - the USP18-mediated negative feedback loop in the JAK-STAT pathway. (c) Time traces of a delayed negative feedback system in response to repetitive stimulations. Green – signal; blue – effector/output; red – inhibitor.