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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Parasite Immunol. 2020 Dec 15;43(5):e12808. doi: 10.1111/pim.12808

Figure 2. Potential mechanisms of acquired tick resistance.

Figure 2.

Factors that may drive the dichotomous immune responses to tick bites on permissive or resistant host species include: Optimal (A) or suboptimal (A’) engagement of salivary proteins with host defense responses; genetic predisposition to decreased (B) or increased (B’) inflammatory responses to salivary proteins; structural and immunological differences in the skin (C, C’); Host-specific salivary proteome that is sufficient (D) or deficient (D’) in modulating host defense responses; and differences in wound healing without scar (E) or with scar (E’) formation.