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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Brain Behav Immun. 2021 Feb 17;94:210–224. doi: 10.1016/j.bbi.2021.02.005

Figure 7. Therapeutic administration of sEVs Exo(+) (i.t.) reverse mechanical allodynia induced by CFA in male mice.

Figure 7.

(A) Exo(+) treatment attenuated mechanical pain but did not alter thermal sensitivity in the CFA model. Schematic of in vivo experiment; 8-week-old male C57BL/6 mice injected with CFA followed by an i.t. injection of saline, or 1µg Exo(−) or Exo(+). Mechanical sensitivity was determined using von Frey filaments in CFA or saline treated mice. At 48 h, Exo(+) reduced mechanical allodynia induced by CFA which lasted for 8 days (n=3). sEVs injections did not alter responses in saline treated mice. No significant difference was seen for thermal sensitivity. Data shown are mean ± SEM. Statistical analysis was determined by repeated measures two-way ANOVA with Bonferroni post-test *p < 0.05, **p < 0.01, ****p < 0.0001.