Table 2.
Comparing results of AmpFire (Test) and Roche LA-HPV (Reference) for 15 HR-HPV types from 149 specimens (n=2235).
HPV type | P/P | P/N | N/P | N/N | Concordance (%) | Kappa (95% CI) | Prevalence Test | Prevalence Reference |
---|---|---|---|---|---|---|---|---|
HPV16 | 42 | 6 | 4 | 97 | 139/149 (93.3) | 0.84 (0.68–1.00) | 32.2 | 30.9 |
HPV18 | 17 | 6 | 5 | 121 | 138/149 (92.6) | 0.71 (0.55–0.87) | 15.4 | 14.8 |
HPV31 | 9 | 20 | 1 | 119 | 128/149 (85.9) | 0.40 (0.27–0.54) | 19.5 | 6.7 |
HPV33 | 19 | 13 | 2 | 115 | 134/149 (89.9) | 0.66 (0.50–0.81) | 21.5 | 14.1 |
HPV35 | 23 | 11 | 3 | 112 | 135/149 (90.6) | 0.71 (0.55–0.87) | 22.8 | 17.4 |
HPV39 | 10 | 9 | 6 | 124 | 134/149 (89.9) | 0.51 (0.35–0.67) | 12.8 | 10.7 |
HPV45 | 12 | 7 | 1 | 129 | 141/149 (94.6) | 0.72 (0.56–0.88) | 12.8 | 8.7 |
HPV51 | 20 | 12 | 3 | 114 | 134/149 (89.9) | 0.67 (0.51–0.82) | 21.5 | 15.4 |
HPV52 | 29 | 12 | 11 | 97 | 126/149 (84.6) | 0.61 (0.44–0.77) | 27.5 | 26.8 |
HPV53 | 29 | 11 | 2 | 107 | 136/149 (91.3) | 0.76 (0.60–0.92) | 26.9 | 21.5 |
HPV56 | 13 | 11 | 1 | 124 | 137/149 (91.9) | 0.64 (0.48–0.79) | 15.4 | 9.4 |
HPV58 | 23 | 13 | 6 | 107 | 130/149 (87.2) | 0.62 (0.46–0.79) | 24.2 | 19.5 |
HPV59 | 16 | 5 | 2 | 126 | 142/149 (95.3) | 0.79 (0.63–0.95) | 14.1 | 12.1 |
HPV66 | 14 | 6 | 5 | 124 | 138/149 (92.6) | 0.67 (0.51–0.84) | 13.4 | 12.8 |
HPV68 | 12 | 25 | 9 | 103 | 115/149 (77.2) | 0.28 (0.13–0.43) | 24.8 | 14.1 |
15 HR-HPVs | 288 | 167 | 61 | 1719 | 2007/2235 (89.8) | 0.65 (0.61–0.69) |
P; positive, N; negative, Data represented as the ratio of AmpFire/Roche LA-HPV results, Prevalence is shown as percentage.