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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Parasite Immunol. 2021 Jan 11;43(5):e12816. doi: 10.1111/pim.12816

Figure 1: The enzootic cycle of Borrelia burgdorferi.

Figure 1:

Throughout the enzootic cycle, B. burgdorferi must adapt to new challenges within the tick. Upon entering the tick, B. burgdorferi must rapidly adapt to changes in environment and upregulate tick-phase genes, while at the same time evade detection by the tick immune system. The influx of blood into the tick gut during the nymphal blood meal promotes the migration of B. burgdorferi to the salivary glands and eventual entry into the host, where it must again adjust to environmental changes. B. burgdorferi associated changes are indicated in green boxes, changes in the tick are indicated in brown boxes. Created with BioRender.com.