Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

letter

. 2021 Apr 2;14(2):e003262. doi: 10.1161/CIRCGEN.120.003262

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 American Heart Association, Inc.

PMC Copyright notice

Figure. — Concordance of polygenic scores among related individuals. Two-dimensional correlation heat maps of polygenic scores for coronary artery disease (CAD) between pairs of monozygotic twins (A), siblings (B), and second-degree relatives (C). D, The percentage of individuals with a sibling’s polygenic score above a certain threshold percentage who also share a similarly increased polygenic score for 4 cardiometabolic diseases. Polygenic scores were normalized to have a mean of 0 and SD of 1 as performed previously.^1–3 Among sibling pairs with discordant disease status, median polygenic score was higher in the afflicted siblings for each of the 4 diseases, with effect ranging from 0.22 to 0.44 SD units (P<0.001 by paired Wilcoxon rank-sum test for each; E).