Predicted probability of clinically significant depressive symptoms (CES-D scores ≥ 20) as a function of person-centered CRP and cancer-related stress. Elevated CRP was associated with increased probability of exhibiting clinically significant depressive symptoms only among women who reported high cancer-related stress. Models were adjusted for age, BMI, race, surgery, cancer stage and receipt of chemotherapy, radiation therapy and endocrine therapy. Shaded areas depict confidence intervals of simple slopes. The asterisk symbols (*) index statistically significant simple slopes (p < .05).