Table 1. Demographics and Biological Variables for the Study group.

The study group includes LLMD (N = 27) and Controls (N = 17). The percent of the total sample are reported for sex and APOE status. The mean, SD and group-comparison are reported for age, education, Hamilton Depression Rating Scale (HAM-D), and Mini-Mental State Examination score are listed under demographics. Significant differences were found only on the HAM-D (p < 0.001), there were no other significant group differences for the demographic or clinical variables. The means and SDs for the biological variables are listed. As reported in the Results section, there was a significant difference between the LLMD and controls for BChE.

	Control Mean (SD)	LLMD Mean (SD)
N	17	27
Sex (female, % of total)	10 (58.8)	9 (33.3)
APOE Status (positive, % of total)	3 (17.6)	11 (40.7)
Demographics			Independent Samples T-Test (p-value)
Age (years)	67.65 (6.74)	66.67 (5.36)	p = 0.60
Education (years)	16.59 (2.79)	16.44 (2.70)	p = 0.87
MMSE (score) - Screening Visit	29.47 (0.51)	29.74 (0.66)	p = 0.16
Hamilton Depression Rating Scale (Score) - Screening Visit	1.12 (1.90)	16.56 (10.22)	p < 0.001*
Biological Variables
CSF AChE (mU/mL)	60.85 (15.79)	53.13 (19.07)
CSF BChE (mU/mL)	37.50 (10.35)	29.34 (11.70)
CSF IL-6 (pg/mL)	4.87 (5.27)	4.53 (3.08)
CSF IL-8 (pg/mL)	96.46 (32.75)	86.62 (15.40)
CSF C3 (ng/mL)	12247.78 (8377.14)	8187.21 (4805.54)
CSF sTREM2 (pg/mL)	5361.55 (2802.26)	3609.23 (2691.04)
Plasma IL-6 (pg/mL)	2.46 (1.50)	2.20 (1.46)
Plasma IL-8 (pg/mL)	5.24 (2.73)	7.33 (3.96)

^*indicates signifcant difference