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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Autoimmun Rev. 2021 Mar 14;20(5):102804. doi: 10.1016/j.autrev.2021.102804

Table 2.

Aberrant antibody glycosylation observed in autoimmune diseases.

Glycosylation RA SLE CD UC AAV PBC PSC
Agalactosylation IgG↑ [104, 105, 107, 108] IgG↑ [119, 120] IgG↑ [124, 126] IgG↑ [124, 126] IgG↑ [133, 134] IgG1 and IgG2 ↑ [86] IgG1 ↑ [86]
Galactosylation IgG↓ [9799, 102, 103, 105, 106] IgG ↓ [121] IgG↓ [124, 125, 127] IgG↓ [124, 125, 127] IgG↓ [134] IgG1↓ [86] IgG↓ [86, 142]
Asialylation IgG↑ [108] IgA1/2↑ [86]
Sialylation IgG↓ [97, 99, 105, 110] IgG ↓ [121] IgG↓ [125, 127] IgG↓ [125] IgG↓ [134, 135] IgG1↓ [142]
Afucosylation IgM J chain↑ [86] IgG2↑ [86]
Fucosylation IgG↑ [97, 103] IgG ↑[122] ↓[121] IgG ↑ [125] IgG↓ [125] IgM J chain↓ [86] IgG4↑ [142]
Bisection IgG↑ [121] IgG1 and IgG2/3 ↑; IgG4↓ [125] IgG↓ [125] IgG1↓ [135] IgA1/2↑ [86] IgG4↑ [142]
Diantennary IgA↑ [86] IgG2/3 ↑[142]