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. 2021 Apr 20;11:8539. doi: 10.1038/s41598-021-87982-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation analysis of EC-SOD concentration with plasma biomarkers for age-related diseases. The bar charts indicate the correlation coefficient (r) between plasma EC-SOD and the concentrations of 11 plasma biomarkers for the entire cohort (a), the Very Old (b), and Centenarians (c). The red and blue bars indicate positive and negative correlations, respectively. The dot plots indicate the association between EC-SOD and adiponectin concentrations in plasma (d) and eGFRcreat (e) in the Very Old (green) and Centenarians (purple). Lines in the dot plot indicate correlation lines and the gray regions surrounding the correlation lines indicate the area for 95% confidence intervals.