Table 1.
Characteristics of participants according to age at enrollment.
| Very old | Centenarians | |||||
|---|---|---|---|---|---|---|
| N | (85–99 years) | N | (100–111 years) | |||
| Age at enrollment, median years (IQR) | 505 | 87.7 | (86.2–88.8) | 595 | 104.9 | (101.7–107.1) |
| Female, no. (%) | 505 | 289 | (57.2) | 595 | 500 | (84.0) |
| Medical history | ||||||
| Diabetes Mellitus, no. (%) | 505 | 79 | (15.6) | 583 | 36 | (6.1) |
| Stroke, no. (%) | 505 | 69 | (13.6) | 590 | 89 | (15.0) |
| Coronary heart disease, no. (%) | 505 | 43 | (8.5) | 590 | 87 | (14.7) |
| Chronic kidney disease, no. (%) | 505 | 73 | (14.4) | 595 | 206 | (34.6) |
| Pneumonia, no. (%) | 505 | 17 | (3.3) | 590 | 94 | (15.9) |
| Biomarkers in plasma | ||||||
| EC-SOD median, ng/mL (IQR) | 505 | 109.5 | (91.0–135.9) | 595 | 147.4 | (120.0–187.3 ) |
| Adiponectin median, ng/mL (IQR) | 505 | 12.1 | (7.2–19.2) | 594 | 18.5 | (13.4–25.2) |
| Hemoglobin A1c median, %, (IQR) | 505 | 5.9 | (5.5–6.1) | 587 | 5.6 | (5.3–5.8) |
| NTproBNP median, ng/mL (IQR) | 475 | 194.0 | (115.5–392.0) | 405 | 911.0 | (450.0–1830.0) |
| eGFRcreat, median, mL/min/1.73m2 (IQR) | 505 | 62.1 | (52.2–71.3) | 595 | 56.2 | (39.0–66.5) |
| Cystatin C median, mg/dL (IQR) | 503 | 1.17 | (1.02–1.36) | 593 | 1.60 | (1.30–1.97) |
| TCHO median, mg/dL (IQR) | 505 | 200.4 | (178.0–221.0) | 595 | 168.0 | (143.0–189.5) |
| HDLC median, mg/dL (IQR) | 505 | 58.2 | (48.0–67.0) | 595 | 48.6 | (40.0–56.0) |
| LDLC median, mg/dL (IQR) | 505 | 113.6 | (95.0–130.0) | 595 | 94.1 | (74.0–112.5) |
| TNF-alpha median, pg/mL (IQR) | 505 | 2.19 | (1.87–2.79) | 595 | 4.24 | (3.30–5.55) |
| Interleukin-6 median, pg/mL (IQR) | 505 | 1.66 | (1.27–2.45) | 595 | 3.15 | (2.36–4.88) |
| CRP median, mg/dL (IQR) | 505 | 0.090 | (0.040–0.180) | 595 | 0.180 | (0.070–0.580) |
| Genotype/sequencing | ||||||
| rs1799895 G allele, no. (MAF) | 1010 | 56 | (0.055) | 1190 | 48 | (0.040) |
| rs1799895 G allele carrier, no. (rate) | 505 | 52 | (0.102) | 595 | 46 | (0.077) |
| Whole genome sequenced, no. (%) | 505 | 0 | (0) | 595 | 351 | (58.9) |
IQR interquartile range, EC-SOD extracellular superoxide dismutase, NT-proBNP N-terminal pro-brain natriuretic peptide, eGFRcreat estimated glomerular filtration rate based on serum creatinine, TCHO total cholesterol, HDLC high-density lipoprotein cholesterol, LDLC low-density lipoprotein cholesterol, TNF-alpha tumor necrosis factor-alpha, CRP C-reactive protein, MAF minor allele frequency.