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. 2021 Apr 20;11:8531. doi: 10.1038/s41598-021-88050-9

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Modified Raynaud scan of impaired vasoreactivity case. (A) High signal intensity in right anterior cerebral artery territory on a diffusion-weighted image. (B) Scan for both hands and standard source. (C) Same blood amount in both hands. Activity % of the total injected dose means the percentage of total blood. (D) Impaired vasoreactivity in the left hand under thermal stress. The amount of blood in the right hand was stable during the scan. The shaded area in Fig. 1 (C,D) represents the reference range obtained from 10 normal volunteers. R: right; L: left; Std: standard.