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. 2021 Apr 20;11:8531. doi: 10.1038/s41598-021-88050-9

Table 3.

Logistic regression analysis according to Raynaud scan results.

Variables Univariate analysis Multivariate analysis*
Crude OR (95% CI) p value Adjusted OR (95% CI) p value
Demographics
Age (years) 0.95 (0.91–0.99) 0.023 0.96 (0.91–1.01) 0.106
Sex 0.69 (0.24–2.00) 0.498
Associated symptoms
Affected limb edema 3.29 (1.03–10.51) 0.045 6.15 (1.40–26.97) 0.016
Abnormal sensation 0.76 (0.25–2.29) 0.621
Conventional risk factors (%)
Hypertension 0.48 (0.18–1.26) 0.135
Diabetes mellitus 0.51 (0.19–1.41) 0.195
Dyslipidemia 0.79 (0.27–2.29) 0.661
Atrial fibrillation 2.10 (0.46–9.58) 0.338
Smoking 2.48 (0.87–7.11) 0.091 0.995 (0.28–3.50) 0.994
Previous stroke 0.52 (0.14–1.92) 0.324
Neurological Severity
Proximal muscle strength 0.95 (0.58–1.56) 0.833
Distal muscle strength 1.12 (0.71–1.77) 0.628
Stenosis of artery
Intracranial 1.12 (0.43–2.96) 0.813
Extracranial 1.72 (0.53–5.63)) 0.369
Distribution of ischemic lesion
Anterior circulation 5.24 (1.34–20.54) 0.018 3.68 (1.01–13.48) 0.049
Cortex 1.95 (0.64–5.92) 0.240
Laboratory findings
White blood cell (103/μl) 1.02 (0.84–1.23) 0.866
Hemoglobin (1003/μl) 1.00 (0.77–1.29) 0.994
Platelet (103/μl) 1.00 (1.00–1.01) 0.502
ESR (mm/hr) 1.00 (0.96–1.04) 0.989
hs-CRP (mg/L) 0.99 (0.94–1.04) 0.622
Total cholesterol (mg/dl) 1.00 (0.99–1.02) 0.806
Triglycerides (mg/dl) 1.00 (1.00–1.01) 0.831
HDL (mg/dl) 1.02 (0.97–1.07) 0.429
LDL (mg/dl) 1.00 (0.98–1.01) 0.832
HbA1c (%) 0.98 (0.70–1.35) 0.883

OR odds ratio, CI confidence interval, ESR erythrocyte sedimentation rate, hs-CRP high sensitivity C-reactive protein, HDL high density lipoprotein, LDL low density lipoprotein, HbA1c hemoglobin A1c.

*Adjusted for age, smoking, affected limb edema, anterior circulation, and cortex.